胱抑素C对2型糖尿病肾病的诊断价值  

Diagnostic value of serum cystatin C on diabetic nephropathy

作　　者：汤建雷[1,2] 袁莉[2] 刘贤称[3] 

机构地区：[1]江苏省连云港市第二人民医院内分泌科,连云港222006 [2]南通大学附属医院内分泌科 [3]南通大学附属医院放疗科

出　　处：《南通大学学报（医学版）》2012年第4期272-274,共3页Journal of Nantong University(Medical sciences)

基　　金：南通市科技计划项目(S-10950);南通大学自然科学基金资助项目(09Z041)

摘　　要：目的:评价胱抑素C对2型糖尿病肾病的诊断价值。方法 :回顾性分析78例2型糖尿病肾病患者,92例2型糖尿病患者(无糖尿病肾病)和87例健康对照患者血清胱抑素C水平。以受试者工作特征(ROC)曲线法分析胱抑素C对2型糖尿病肾病的诊断价值。结果:糖尿病肾病患者血清胱抑素C水平高于无糖尿病肾病的2型糖尿病患者,血清胱抑素C诊断糖尿病肾病的曲线下面积为0.80(95%CI:0.70～0.89)。当胱抑素C取值为1.05 mg/L时,其诊断敏感性为0.73(95%CI:0.58～0.84),特异性为0.73(95%CI:0.54～0.87)。结论:胱抑素C对2型糖尿病肾病的诊断具有较高价值。Objective： To explore the diagnostic value of serum cystatin C on diabetic nephropathy in type 2 diabetes mellitus patients. Methods： Serum cystatin C level in 78 type 2 diabetes mellitus patients with diabetic nephropathy, 92 type 2 diabetes mellitus patients without diabetic nephropathy and 87 healthy controls was determined. The diagnostic power of serum cystatin C was estimated by receiver operating characteristic （ROC） curve analysis. Results： Increased serum cystatin C was observed in type 2 diabetes mellitus patients with diabetic nephropathy. The area under curve （AUC） for serum cystatin C was 0.80 （95%CI：0.70-0.89）. The diagnostic sensitivity and specificity were 0.73 （95%CI：0.58-0.84） and 0.73 （95%C1：0.54- 0.87）, respectively, at the optimal threshold of 1.05 mg/L. Conclusion： Serum cystatin C was an effective biomarker for diabetic nephropathy diagnosis in newly diagnosed type 2 diabetes mellitus patients.

关 键 词：糖尿病肾病 胱抑素C 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]