急性坏死性胰腺炎血液流变学改变及其意义  

The significance of hemorrheologic alternation in acute necrotizing pancreatitis

作　　者：王自法[1] 潘承恩[1] 刘绍诰[1] 梁国光[2] 张梅[1] 

机构地区：[1]西安医科大学第一附属医院肝胆外科，陕西 西安 710061 [2]西安医科大学第一附属医院中西医结合研究所，陕西 西安 710061

出　　处：《中国普通外科杂志》2000年第3期225-227,共3页China Journal of General Surgery

摘　　要：研究急性坏死性胰腺炎 (ANP )血液流变学改变及其在病情演进中的作用。方法　检测ANP大鼠的血液流变学指标 ,红细胞脆性及胰腺病理学检查。结果　ANP大鼠全血粘度 ,血浆粘度 ,红细胞压积均显著升高 ,红细胞脆性增加 ;纤维蛋白原降低。结论　ANP时 ,出现显著血液流变学改变 ,后者可能是胰腺进行性坏死 。Objective To study the hemorrheologic alternation in acute necrotizing pancreatitis(ANP) and its effect in deterioating of ANP. Methods Blood samples were obtained from ANP rats for hemorrheologic examination and erythrocyte osmotic fragility test. Pancreatic tissue was obtained for pathological study. Results Blood viscosity, plasma viscosity, hematocrit, erythrocyte osmotic fragility were significantly elevated, while erythrocyte sedimentation rate and fibrinogen were decreased significantly in ANP rats compared with sham operation group. Conclusions In ANP rats, hemorrheology is altered significantly, which may be one of the important factors in deterioraton the disease.

关 键 词：胰腺炎 病理生理学 血液汉变学 急性病 

分 类 号：R657.510.2[医药卫生—外科学]