低分子量肝素治疗急性出血坏死性胰腺炎的实验研究  

Low molecular weight heparin for acute hemorrhagic necrotizing pancreatitis in rabbits

作　　者：李介秋 张开诚 吕新生[2] 肖创清 夏洪志 

机构地区：[1]解放军第一六三中心医院外科,湖南长沙410003 [2]湖南医科大学附属湘雅医院普外科,湖南长沙410008 [3]解放军第一六三中心医院检验科,湖南长沙410003

出　　处：《中国普通外科杂志》2000年第3期234-236,共3页China Journal of General Surgery

摘　　要：探讨低分子量肝素 (LMWH )对急性出血坏死性胰腺炎 (AHNP)的治疗作用。方法　将 60只大白兔制作成AHNP模型后随机分为两组 :治疗组 (n =3 0 )用低分子量肝素治疗 ;对照组 (n =3 0 )用盐水替代肝素 ,对比两组动物的生存率和血清肿瘤坏死因子(TNF)、淀粉酶 (AMS)、血栓烷B2 (TXB2 )、一氧化氮 (NO )、超氧化物歧化酶 (SOD )和丙二醛(MDA )。结果　治疗组生存率高于对照组 (P <0 .0 1) ;治疗组血清TNF ,AMS ,TXB2 ,NO ,SOD ,MDA显著低于对照组 (P <0 .0 1)。结论　LMNH能降低AHNP兔的TNF ,NO ,AMS ,TXB2 水平 ,抑制MDA产生 ,可改善AHNP兔微循环障碍 。Objective To explore the effect of low molecular weight heparin(LMWH) for acute hemorrhagic necrotizing pancreatitis(AHNP). Methods A model of AHNP was created according to Klar's method. Sixty AHNP rabbits were devided randomly into two groups, the treatment group(TG) treated by LMWH; the control group(CG) treated by nomal saline only. The survival rate(SR), levels of TNF, AMS, TXB 2, NO, SOD and MDA in serum of TG were compared with CG. Results The SR in TG was obviorsly higher than those in CG( P <0.01); serum levels of TNF, AMS, TXB 2, NO, SOD and MDA in TG were obviously lower than those in CG( P <0.01). Conclusions LMWH plays a role in AHNP treatment by reducing levels of TNF, NO, AMS and TXB 2, inhibiting MDA production and improving the microcirculation disorders in rabbits with AHNP.

关 键 词：肝素 治疗 胰腺 肿瘤坏死因子 

分 类 号：R657.510.5[医药卫生—外科学]