含1,3,4-噻二唑环氟取代苯基脲的合成及细胞分裂素活性  

Synthesis and cytokinin activity of fluorinated phenylureas containing 1,3,4-thiadiazole unit

作　　者：宋新建[1] 邓仕明[2] 杨平[1] 邵宇[1] 

机构地区：[1]湖北民族学院生物资源保护与利用湖北省重点实验室,湖北恩施445000 [2]湖北民族学院医学院,湖北恩施445000

出　　处：《化学试剂》2012年第7期612-614,619,共4页Chemical Reagents

基　　金：湖北省自然科学基金资助项目(2011CDB087);生物资源保护与利用湖北省重点实验室开放基金资助项目(PKLHB1102)

摘　　要：以取代肉桂酸和氨基硫脲为原料、以三氯氧磷为脱水剂经缩合-环化"一锅法"制备2-氨基-5-取代苯乙烯基-1,3,4-噻二唑,再与含氟苯甲酰基叠氮化物反应合成9种新的含氟取代苯基脲类化合物。其结构经红外光谱、核磁共振氢谱、质谱和元素分析所确认。初步的生物活性测试表明,目标化合物在10 mg/L浓度下表现出良好的细胞分裂素活性,促进率超过50%。Nine novel fluorinated phenylureas were synthesized by reaction of fluorine-containing benzoyl azides with 2-amino-5-（substituted styryl）-1,3,4-thiadiazoles,which were prepared by one-pot procedure through the condensation-cyclization of substituted cinnamic acid and thiosemicarbazide with POCl3 as dehydrating agent.The structures of these title compounds were confirmed by IR,1HNMR,MS and elemental analysis.The preliminary bioassay showed that compound exhibits good cytokinin activity at the concentration of 10 mg/L,and its promoting rate exceeds 50%.

关 键 词：1 3 4-噻二唑 脲 含氟衍生物 细胞分裂素 

分 类 号：O621.29[理学—有机化学]