拉氧头孢钠的合成  

Synthesis of latamoxef disodium

作　　者：米国瑞[1] 张月成[1] 赵继全[1] 

机构地区：[1]河北工业大学化工学院,天津300130

出　　处：《化学试剂》2012年第7期654-656,672,共4页Chemical Reagents

摘　　要：拉氧头孢母核经四氮唑巯基取代、甲氧化、侧链裂解得到7β-氨基-7α-甲氧基-3-(1-甲基-5-四唑基)硫甲基-1-氧杂去硫杂-3-头孢烯-4-羧酸二苯甲酯,再经酰化、脱羧酸保护基、成盐反应制得目标化合物,总收率约30%,纯度为97.2%。Latamoxef disodium was synthesized from latamoxef nucleus by thiadiaazolythio group substitution,methoxylation,side chain cleavage to give diphenylmethyl-7β-amino-7α-methoxy-3-（1-methyltetrazol-5-yl）-thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylate,which was subjected to acylation,deprotection of carboxy-protection group,salt formation with an overall yield of about 30% and purity of 97.2%.

关 键 词：拉氧头孢钠 拉氧头孢 氧头孢烯 抗生素 

分 类 号：O626.2[理学—有机化学]