复方苦豆子对肾性高血压复合高脂血症大鼠血压和血脂的影响  

Effects of compound Kudouzi on blood pressure and blood lipids in rats with renal hypertension complicated by hyperlipidemia

作　　者：刘晓敏[1] 陈虹[2] 

机构地区：[1]吉林医药学院附属医院,吉林132013 [2]石河子大学省部共建新疆特种植物药资源教育部重点试验室,石河子832002

出　　处：《中国新药杂志》2012年第13期1528-1531,1557,共5页Chinese Journal of New Drugs

摘　　要：目的:探讨复方苦豆子对肾性高血压复合高脂血症大鼠血压、血脂的影响及可能的机制。方法:建立肾性高血压复合高脂血症大鼠模型,随机分为模型组,复方苦豆子高、中、低剂量组,阳性对照组,每组12只。另取10只为假手术组。试验8周。每周末测定大鼠尾动脉收缩压(SBP);给药前及给药4,8周后测定大鼠血浆总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C);给药8周后测定大鼠血浆肾素活性(PRA)、AngII水平。结果:与模型组比较,药物高、中剂量组SBP,TC,TG,LDL-C及AngII水平明显降低(P<0.01);HDL-C,PRA水平明显升高(P<0.01)。结论:复方苦豆子可降低模型大鼠血压,调节血脂,其机制可能与肾素-血管紧张素系统的调节有关。Objective： To investigate the effects of compound Kudouzi on blood pressure and blood lipids in rats with renal hypertension complicated by hyperlipidemia and its possible mechanism. Methods： Rat model of renal hypertension complicated by hyperlipidemia was established. The model rats were randomly divided into mod- el group, compound Kudouzi high, medium and low dose group, positive control group （n = 12） and sham group （n = 10）. Rat tail artery systolic blood pressures （SBP） were measured every weekend; total cholesterol （TC）, triglyceride （TG） , high density lipoprotein （HDL-C） and low density lipoprotein （LDL-C） in plasma were meas- ured at week 0, 4 and 8. PRA and AnglI levels in plasma were measured at week 8. Results： Compared with mod- el group, compound Kudouzi of high and middle doses significantly decreased SBP, TC, TG, LDL-C and AnglI levels and increased HDL-C and PRA levels at the same time （P 〈 0.01 ）. Conclusion： Compound Kudouzi can reduce blood pressure and regulate blood lipids, which may be related to the regulation of renin-angiotensin system.

关 键 词：复方苦豆子 肾性高血压复合高脂血症 血压 血脂 

分 类 号：R961[医药卫生—药理学]