幽门螺杆菌感染与脑梗死的相关性研究  

Correlation between Helicobacter pylori infections and cerebral infarctions

作　　者：周广安[1] 

机构地区：[1]泰安市中心医院神经内科,山东泰安271000

出　　处：《中华医院感染学杂志》2012年第14期3066-3067,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨幽门螺杆菌(Hp)感染与脑梗死的相关性,为临床诊治该病提供依据。方法选取2010年1月至2012年1月医院收治的新发脑梗死患者56例为脑梗死组,另选取同期健康者49例为对照组,比较两组Hp特异性抗体阳性率及脑梗死相关因子水平。结果脑梗死组患者Hp特异性抗体IgG、IgA和IgM阳性率显著高于对照组,差异有统计学意义(P<0.05);脑梗死组患者CRP、TCH、TG、TNF-α及Fib水平显著高于对照组,两组比较差异有统计学意义(P<0.05)。结论 Hp感染与脑梗死的发生密切相关,可能是脑梗死的又一危险因素,且脑梗死患者血脂、C-反应蛋白和纤维蛋白原发生显著变化,对判断患者的病情及预后有一定的意义。OBJECTIVE To explore the correlation between Helicobacter pylori（Hp） infections and cerebral infarctions,and offer a reference for diagnosis and treatment of the disease.METHODS From Jan.2010 to Jan.2012,totally 56 patients with newly cerebral infarctions were set as the cerebral infarction group,meanwhile,49 healthy people were set as the control group;the positive rate of Hp specific antibody and the levels of cerebral infarction-related factors were compared between the two groups.RESULTS The positive rates of IgG,IgA and IgM were significantly higher in the cerebral infarction group than in the control group,the differences were statistically significant（P0.05）;the levels of CRP,TCH,TG,TNF-α and Fib were significantly higher in the cerebral infarction group than in the control group,the differences were statistically significant（P0.05）.CONCLUSION There is close relation between the Hp infections and the cerebral infarctions.It is probably another risk factor for cerebral infarctions;and the significant change of the levels of blood lipid,CRP and Fibrinogen has certain significance in the judgment of condition and prognosis of the patients.

关 键 词：脑梗死 幽门螺杆菌 感染 相关性 

分 类 号：R181.32[医药卫生—流行病学]