呼吸内科抗菌药物使用强度分析  

Antibiotic use intensity in department of respiratory medicine

作　　者：吴镝[1] 崔霞[1] 何晓锋[1] 刘芳[1] 张虎[1] 马文杰[1] 曹晋桂[1] 

机构地区：[1]空军总医院感染控制科,北京100142

出　　处：《中华医院感染学杂志》2012年第14期3132-3133,共2页Chinese Journal of Nosocomiology

摘　　要：目的为开展抗菌药物专项整治活动提供依据,提高医院抗菌药物合理使用水平。方法回顾性调查2012年1-4月医院呼吸内科315例出院患者的基本用药情况,以限定日剂量(DDD)分析法对用药频率(DDDs)和使用强度(AUD)进行统计分析。结果 2012年1-4月AUD分别为120.4、163.2、132.7、100.9DDD;送检率均>70.0%,DDDs排序前3位的药物分别为左氧氟沙星、哌拉西林/舒巴坦、头孢唑肟。结论医院呼吸内科抗菌药物临床使用中以β-内酰胺类抗菌药物占主导地位,使用强度与卫生部要求力争<40DDD相差较大;随着抗菌药物的大量使用,细菌耐药性不断发展,应严格按照《抗菌药物临床应用指导原则》合理使用。OBJECTIVE To provide basis for conducting the special rectification of use of antibiotics so as to improve the reasonable use of antibiotics.METHODS Totally 315 patients who discharged from the respiratory medicine department from Jan to Apr were enrolled in the study,the use of antibiotics was retrospectively analyzed;by means of defined daily doses（DDD） analysis,the intensity of the frequency of administration（DDDs）,and the antibiotic use density（AUD） were statistically analyzed.RESULTS The AUD from Jan to Apr were 120.4 DDD,163.2 DDD,132.7 DDD,and 100.9 DDD,respectively;the submission rates were all higher than 70.0%,the top three DDDs of the antibiotics were levofloxacin,piperacillin/sulbactam,and ceftizoxime.CONCLUSION The beta-lactam antibiotics are dominant antibiotics used in the department of respiratory department,the AUD remains 40 DDD less than the requirements of Ministry of Health.With the extensive use of antibiotics and the increase of bacterial resistance,it is necessary to reasonably use antibiotics strictly in accordance with guidelines for clinical use of antibiotics.

关 键 词：限定日剂量 使用强度 用药频度 

分 类 号：R978.1[医药卫生—药品]