医院感染多药耐药菌的临床调查与药敏分析  

Drug susceptibility of multidrug-resistant bacteria causing nosocomial infections

作　　者：佟青[1] 张一兵[1] 刘阳[2] 

机构地区：[1]辽宁医学院附属第三医院医院感染控制处,辽宁锦州121000 [2]辽宁医学院附属第三医院医院医学检验中心,辽宁锦州121000

出　　处：《中华医院感染学杂志》2012年第14期3166-3168,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解医院感染多药耐药菌的分布及耐药性,提高预防感染水平,指导临床合理使用抗菌药物。方法对2011年1-7月临床标本按常规进行病原菌分离,采用VITEK-IMS全自动细菌鉴定与药敏分析仪,对病原菌进行鉴定。结果共检出病原菌230株,其中多药耐药菌129株,检出率为56.1%;革兰阳性多药耐药菌检出率为4.8%,主要为金黄色葡萄球菌占0.9%,屎肠球菌占3.9%;革兰阴性多药耐药菌检出率为45.0%,主要为大肠埃希菌占16.9%、肺炎克雷伯菌占13.0%。结论医院分离的多药耐药菌分布与卫生部公布的主要多药耐药目标菌有一定差异,提示临床医师在使用抗菌药物时应根据病原菌的分离株种类、耐药性特点及药敏试验,合理选用抗菌药物。OBJECTIVE To investigate the distribution and drug resistance of multiple drug resistant bacteria causing nosocomial infections so as to raise the level of infection prevention and guide clinical rational administration.METHODS The specimens of nosocomial infection were isolated routinely from Jan to Jul 2011;the identification of bacteria and drug susceptibility testing were finished by VITEK2 automatic microbial analyzer.RESULTS A total of 230 strains of pathogenic bacteria were isolated,including 129（56.1%） multidrug-resistant bacteria.The isolation rate of gram-positive multidrug-resistant bacteria was 4.8%,Staphylococcus aureus accounted for 0.9% and Enterococci accounted for 3.9%;the isolation rate of gram-negative multidrug resistant bacteria was 45.0%,Escherichia coli accounted for 16.9%,Klebsiella pneumoniae accounted for 13.0%.CONCLUSION The distribution of multiple resistant bacteria isolated in our hospital is partly different from the target strains reported by the Ministry of Health,which indicates that the antibiotics should be used reasonably on the basis of the species of the pathogens isolated,drug resistance as well as the drug susceptibility testing.

关 键 词：多药耐药菌 变化趋势 耐药率 

分 类 号：R378[医药卫生—病原生物学]