暑热宁合剂提取工艺优化  

Optimization of Extraction Process for Shurening Mixture

作　　者：张元元[1] 李进[2] 陈涛[2] 李凤丽[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津中医药大学第一附属医院,天津300193

出　　处：《中国实验方剂学杂志》2012年第14期49-51,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"重大新药创制"科技重大专项(2010ZX09102-201)

摘　　要：目的:优选暑热宁合剂提取工艺。方法:以葛根素及绿原酸为考察指标,HPLC测定指标成分含量。选取提取次数、提取时间和加水量等为考察因素,采用正交试验法对进行提取工艺优选。结果:暑热宁合剂最佳提取条件为加10倍量水提取3次,每次1.5 h。结论:优选的工艺稳定、可行、重复性好。Objective：To optimize extraction technology of Shurening mixture.Method：Taking puerarin and chlorogenic acid as indexes,the content of index components were determined by HPLC.Orthogonal experiment was applied to optimize extraction technology with extraction times,extraction time and the amount of water as factors.Result：The best extraction conditions were as follows：extracted 3 times with 10-fold the amount of water,1.5 h each time.Conclusion： optimized process was stable and feasible with good repeatability.

关 键 词：暑热宁合剂 葛根素 绿原酸 正交试验 提取工艺 

分 类 号：R283.6[医药卫生—中药学]