芪龙颗粒对肺气虚型变应性鼻炎大鼠血清IL-1和IL-4水平的影响  

Influence of Qilong Granula on IL-1 and IL-4 in Serum in Allergic Rhinitis Rats with Lung Qi Deficiency

作　　者：刘瑶[1] 彭顺林[1] 尹红[2] 邓婧[2] 李菁[1] 王平[1] 蔡青[1] 

机构地区：[1]成都中医药大学,成都610075 [2]成都中医药大学附属医院,成都610075

出　　处：《中国实验方剂学杂志》2012年第14期224-226,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：四川省科技支撑计划项目(2010SZ0144);四川省中医药管理局科技项目(CKY2010012);成都中医药大学科技发展基金(ZRYB200905)

摘　　要：目的:探讨芪龙颗粒治疗变应性鼻炎(AR)的疗效机制。方法:将自由喂养1周大鼠,按雌雄随机分为4组,即空白对照组,肺气虚型AR模型组,芪龙颗粒组,阳性药物辛芩颗粒组,每组15只。用刨花烟熏的基础上,以卵清蛋白致敏造成肺气虚型AR大鼠模型,予以芪龙颗粒(20 g.kg-1)、辛芩颗粒(20 g.kg-1)治疗2周,采用免疫荧光法检测大鼠血清IL-1,IL-4的含量。结果:模型组大鼠血清IL-1,IL-4[(127.67±4.58),(106.87±2.04)ng.L-1]水平明显高于空白组(P<0.01),芪龙组IL-1,IL-4[(86.95±4.54),(74.35±2.63)ng.L-1],辛芩组[(104.61±3.85),(88.67±2.06)ng.L-1]均明显低于模型组(P<0.01),芪龙组水平明显低于辛芩组(P<0.01)。结论:芪龙颗粒可降低肺气虚型AR大鼠血清IL-1,IL-4水平,可能是治疗肺气虚型AR的作用机制之一。Objective：To study the mechanism of Qilong granula for treating allergic rhinitis（AR）.Method： Rats were feeded for one week then randomly divieded into four groups according to male and female： Blank control group,lung qi deficiency of allergic rhinitis model group,Qilong granula group and positive drug Xinqin granula group,（n=15 each）.Qilong granula（20 g·kg-1） and Xinqin granula（20 g·kg-1） were treated for two weeks accordingly.The content of interleukin-1（IL-1） and interleukin-4（IL-4） was datermined in serum with immunofluorescence method in each group.Result： The levels of IL-1（127.67±4.58）ng·L-1 and IL-4（106.87±2.04）ng·L-1 in model group were obviously higher than in blank control group（P0.01）.IL-1（86.95±4.54）ng·L-1,IL-4（74.35±2.63）ng·L-1 in Qilong granula groups and IL-1（104.61±3.85）ng·L-1,IL-4（88.67±2.06）ng·L-1 in Xinqin granula group were lower than those in model group（P0.01）.The levels of Qilong granula groups were obviously lower than Xinqin granula group（P0.01）.Conclusion： Qilong granula could descent the serum IL-1 and IL-4 in allergic rhinitis with lung qi deficiency.This may be one of posible effect on AR with lung qi deficiency.

关 键 词：芪龙颗粒 变应性鼻炎 肺气虚 白细胞介素1 白细胞介素4 

分 类 号：R285.5[医药卫生—中药学]