泄毒养肝法治疗肝硬化内毒素血症的临床观察  

Clinical Study of Toxin-releasing-and-liver-nourishing Therapy for Hepatic Cirrhosis Complicated by Endotoxemia

作　　者：费建平[1] 林冠凯[1] 史兵伟[1] 许泽君[1] 吴菁[1] 

机构地区：[1]常州市中医医院,江苏常州213003

出　　处：《辽宁中医杂志》2012年第7期1320-1323,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：从住院病人中筛选出肝硬化内毒素血症(Endotoxemia,ETM)患者60例,随机分为治疗组和对照组,分别从临床证候、血清内毒素(Lipopolysaccharide,LPS)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、内皮素-1(En-dothelin-1,ET-1)等指标,分析中医泄毒养肝法临床疗效及安全性。结果提示中医组对症状的疗效优于对照组,在降低LPS、TNF-α以及ET-1方面优于对照组(P<0.05),两组ALT、GGT、T-BIL、AST较治疗前均有改善(P<0.05),两组治疗前后AST以及ALB的差值比较无显著性差异,对ALT、LDH、GGT和T-BIL的降低作用治疗组优于对照组(P<0.05)。未发现不良反应。We selected 60 patients in hospital by strict standards according to the research.The 60 accepted cases were randomly divided into two groups：the treatment group and the control group with 30 cases in each group.Then the levels of LPS,TNF-α and ET-1,Hepatic function and TCM points were measured in all the cases before and after the treatment.At last,the efficacy and the safety of the two therapies with all these data were analyzed.The results showed that the toxin-releasing-and-liver-nourishing therapy was superior to Lactulose for releasing clinical symptoms.The level of the serum endotoxin,TNF-α and ET-1 decreased in both groups,the differences between the two groups were marked（P〈0.05）.The levels of the serums ALT,GGT,T-BIL and AST decreased than that before treatment in both groups（P〈0.05）,the changes of AST and ALB were not with signification（P〈0.05）.To the treatment group,the adjustments of ALT,LDH,GGT and T-BIL were superior to that in the control group（P〈0.05）.There was no adverse effect in the treatment group during the treatment.

关 键 词：肝硬化 内毒素血症 泄毒养肝法 临床研究 

分 类 号：R657.31[医药卫生—外科学]