益母草对紫外线所致皮肤光老化防护作用的研究  

Study on Protecting Effect of Leonurus Japonicus Houtt(LSH)on Rat Skin Photoaging Induced by Ultraviolet Ray

作　　者：徐蓉[1] 吴景东[2] 

机构地区：[1]辽宁中医药大学中医基础理论教研室,辽宁沈阳110032 [2]辽宁中医药大学,辽宁沈阳110032

出　　处：《辽宁中医杂志》2012年第7期1421-1422,共2页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:建立皮肤光老化动物模型并探讨益母草对紫外线所致皮肤光老化的防护作用。方法:采取高剂量中波紫外线和长波紫外线短期联合照射的方法,建立皮肤光老化的实验动物模型。每天每次紫外线光照后的间歇,在紫外线照射区域的皮肤上外涂益母草赋形剂。结果:正常皮肤、紫外线照射和外涂益母草赋形剂皮肤区域的各组小鼠皮肤组织中CAT、MDA、SOD、HyP、GSH-Px的含量均有变化,差异有显著性(P<0.01)。结论:短期高强度的紫外线照射能够引起皮肤光老化的表现;益母草对紫外线照射所致皮肤光老化的损害有保护和修复作用。Objective：To establish the animal model of skin photoaging as well as to study the protective effects of LSH.Methods：The high doses of UVB and UVA radiation in a short-term was used to establish the model.The zone of the model skin was smeared with the excipient LSH in the intermission which ultraviolet radiated every day.Results：Statistics showed the significant difference（P〈0.01）in contents（CAT、MDA、SOD、HyP、GSH-px）compared with the three groups：normal skin,treated region of LSH and ultraviolet radiation skin.Conclusion：A short-term high strength ultraviolet radiation can cause the performance of skin photoaging.LSH has repair and protection effect on skin photoaging caused by ultraviolet light damage.

关 键 词：益母草 皮肤光老化 羟脯氨酸 

分 类 号：R285.5[医药卫生—中药学]