琼脂糖醋酸酯纳米粒子的制备及药物缓释性  

Preparation and in Vitro Controlled Release of Drug-Loaded Agarose Acetate Nanoparticles

作　　者：张令辉[1] 尤玲玲[1,2] 张灵敏[2] 汤顺清[2] 蔡继业[1] 

机构地区：[1]暨南大学化学系 [2]暨南大学生物医学工程研究所,广东广州510632

出　　处：《高分子材料科学与工程》2012年第7期116-119,123,共5页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(30872404)

摘　　要：通过纳米沉淀法制备了一种粒径均一的琼脂糖醋酸酯纳米粒子,并对影响粒径的相关因素进行了研究。结果表明,纳米粒子分别随着二甲基亚砜(DMSO)与水的比率、姜黄素含量及琼脂糖醋酸酯(AA)的浓度的增加而增大,随转速的增加而下降,异丙醇和聚乙烯醇(PVA)浓度也有一定的影响。同时研究了载体对姜黄素的包载情况及缓释行为。结果显示,无异丙醇组中姜黄素载药率和包封率均比异丙醇组中的高。但两组都表明,随着姜黄素的含量增加,载药粒子的载药率不断增加,包封率不断降低。载药粒子大大延长了姜黄素的缓释时间。获得的琼脂糖醋酸酯纳米粒子可望用于姜黄素的控释。In this paper, the preparation of uniform agarose acetate nanoparticles （AA-NPs） by nanoprecipitation was investigated with the following conditions： （1） emulsifier PVA concentration, （2） co-emulsifier isopropanol, （3） AA concentration, （4） the ratio of dimethyl sulfoxide （DMSO） to water, （5） the stirring rate, and （6） drug content. The results show that the size of AA-NPs has a close relationship with conditions above. In addition, the drug loading capacity and in vitro drug release of the AA-C-NPs were investigated. The results show that the loading rate and encapsulation efficiency of AA-C-NPs without isopropanol are higher than that with isopropanol. But both of them show a tendency that the loading rate obviously increases but encapsulation efficiency decreases with increasing of initial curcumin concentration. The result of in vitro release shows a burst effect at the beginning stage, a slow and continuous release followed.

关 键 词：琼脂糖醋酸酯 纳米粒子 影响因素 姜黄素 缓释 

分 类 号：R318.08[医药卫生—生物医学工程] Q636.1[医药卫生—基础医学]