PEG-400中一锅法合成4H-吡喃衍生物  

One-pot synthesis of 4H-pyrans derivatives in PEG-400

作　　者：巩海鹏[1] 王喜存[2] 叶鹤琳[3] 

机构地区：[1]甘肃农业大学理学院,甘肃兰州730070 [2]西北师范大学化学化工学院,甘肃兰州730070 [3]兰州城市学院化学与环境科学学院,甘肃兰州730070

出　　处：《化学研究与应用》2012年第7期1164-1168,共5页Chemical Research and Application

摘　　要：PEG-400作反应介质,90℃下通过芳醛、1,3-二羰基化合物和丙二腈三组份缩合反应,一锅法合成了11种6-氨基-5-腈基-4-芳基-2-甲基-4H-吡喃类衍生物。产物结构经IR、1H NMR、13C NMR及Elemental Analysis得到确证。该方法具有产率高、操作简单、环境友好等优点。An efficient protocol for the one-pot three-component synthesis of various 6-amino-5-cyano-4-aryl-2-methyl-4H-pyrans by the reaction of aldehydes,ethyl acetoacetate or acetylacetone and malonitrile using PEG-400 as reaction medium at 90℃ was described.The structures of all compounds were confirmed by IR,1H NMR,13C NMR and Elemental analysis.This method had the advantages of good yields,easy work-up and environmentally friendly procedure.

关 键 词：4H-吡喃 PEG-400 丙二腈 合成 

分 类 号：O626.3[理学—有机化学]