齐墩果酸对高血糖大鼠胰岛素及肝糖原含量的影响  

Effects of the Oleanolic Acid on Insulin and Liver Glycogen Store in Diabetic Rats

作　　者：谢灵璞 

机构地区：[1]象山县食品药品监督管理局,浙江象山315700

出　　处：《中华中医药学刊》2012年第7期1669-1670,I0015,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:通过研究齐墩果酸对高血糖大鼠的血糖、血清胰岛素及肝糖原含量的影响,探讨齐墩果酸的降血糖作用。方法:通过测定链脲菌素制备高血糖大鼠的空腹血糖(FBG)、血清胰岛素(FINS)、肝糖原含量及观察肝脏PSA染色,来评价齐墩果酸降血糖作用。结果:齐墩果酸明显降低高血糖大鼠FBG(P<0.01),升高高血糖大鼠FINS及肝糖原含量(P<0.05),肝脏PSA切片观察:齐墩果酸紫红色糖原较模型组明显增多。结论:齐墩果酸可能通过增加肝糖原含量及升高血清胰岛素水平降低血糖。Objective：To study the effects of oleanolic acid on insulin and liver glucogen store on diabetic rat and to evaluate the hypoglycemie activity of oleanolic acid and the mechanism.Methods：FBG,FINS and liver glycogen store were measured and PSA staining was observed,and the hypoglycemic effect of oleanolic acid was evaluate.Results：Oleanolic acid significantly reduced FBG（P〈0.01）,elevated liver glycogen store and FINS（P〈0.05）.PSA observation：oleanolic acid purple glycogen increased significantly than that in model group.Conclusion：Oleanolic acid may be through increasing glycogen content and serum levels of insulin to lower blood sugar.

关 键 词：齐墩果酸 高血糖 胰岛素 肝糖原 

分 类 号：R285.5[医药卫生—中药学]