循环血液中内皮祖细胞在充血性心力衰竭患者中的表达  

Expression of endothelial progenitor cells with the blood circulation in congestive heart failure

作　　者：余东彪[1] 吴继雄[1] 

机构地区：[1]安徽医科大学第二附属医院,合肥230601

出　　处：《山东医药》2012年第28期23-25,共3页Shandong Medical Journal

摘　　要：目的研究内皮祖细胞在充血性心力衰竭患者中的表达情况,并进一步研究其与心衰严重程度的相关性。方法选择心衰患者96例(纽约心功能分级:Ⅰ级22例,Ⅱ级25例,Ⅲ级26例,Ⅳ级23例)及健康正常人25例(对照组),以CD34、CD45为表面标记,用流式细胞仪测量外周血中的内皮祖细胞数,并同时测量脑钠肽(BNP)。结果心衰患者较对照组BNP水平升高(P<0.01),且心衰的严重程度与BNP呈正相关;在心功能Ⅰ级、Ⅱ级心衰患者中,内皮祖细胞较健康对照组明显升高(P<0.01);心功能Ⅲ级、Ⅳ级患者较健康对照组降低(P<0.05或<0.01)。结论内皮祖细胞在心衰患者中呈现一个双向性改变,即在心衰晚期阶段外周血内皮祖细胞表达较对照组明显下降,而在心衰早期阶段较对照组明显升高,提示受损的内皮祖细胞招募可能参与严重心衰患者的病理生理过程。Objective To investigate the pattern of endothelial progenitor cells during congestive heart failure and their correlation with the severity. Methods 96 patients with heart failure （ NYHA Class I： 22 cases, Ⅱ ： 25 cases, Ⅲ ： 26 cases, Ⅳ： 23 cases） and 25 cases of normal control group were measured CD34, CD45, peripheral blood endothelial progenitor cells number with flow cytometric and simultaneously measured brain natriuretic peptide （BNP） level. Results The heart failure patients increased significantly BNP levels than the control group, and the severity of the heart failure with BNP was positively correlated. Endothelial progenitor cells were increased in NYHA Class I and NYHA Class Ⅱ com- pared with that in controls （ P 〈 0.01 ）. Endothelial progenitor cells were significantly decreased in NYHA Class Ⅳ and NYHA Class Ⅲ compared with that in controls （ P 〈 0.05 or P 〈 0.01 ）. Conclusions Endothelial progenitor cells in the heart failure patients show a biphasic response, with elevation and depression in the early and advanced phases, respectively. These findings suggest that impaired endothelial progenitor cells recruitment might be involved in the pathophysiology of severe heart failure.

关 键 词：心力衰竭 内皮祖细胞 脑钠肽 

分 类 号：R541.6[医药卫生—心血管疾病]