和厚朴酚桥连卟啉光敏剂合成与结构表征  

Synthesis and Characterization of Honokiol Bridged Porphyrins as Photosensitizers

作　　者：黄齐茂[1] 王司卫[1] 邓鹏星[1] 周红[1] 胡学雷[1] 潘志权[1] 

机构地区：[1]武汉工程大学化工与制药学院绿色化工过程省部共建教育部重点实验室,武汉430073

出　　处：《有机化学》2012年第7期1344-1349,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20471045);湖北省自然科学基金青年杰出人才(No.2008CDB072);湖北省高等学校优秀中青年团队计划(2008)资助项目~~

摘　　要：依次利用2-萘酚、1,6-二溴己烷、和厚朴酚,对2-硝基-5,10,15,20-四苯基卟啉及其金属配合物进行结构修饰,首次得到四对同分异构体桥连卟啉光敏剂,目标产物经UV-Vis,1H NMR,H-H COSY,IR,MS,元素分析等表征.以1,3-二苯基异苯并呋喃(DPBF)为猝灭剂测定了桥连卟啉产生单线态氧的能力;采用凝胶电泳和紫外-可见光谱滴定法,初步考察了化合物对pBR322质粒DNA的光敏切割能力及其与小牛胸腺DNA的作用模式.Four pairs of porphyrin isomers have been synthesized by reaction of 2-nitrotetraphenylporphyrin and its metallic complexes with 2-naphthol, 1,6-dibromohexane and honokiol respectively, and structurally characterized by UV-Vis, 1H NMR, H-H COSY, IR, MS, and elemental analysis. The production of singlet oxygen under radiation was determined with 1,3-diphenylisobenzofuran （DPBF） as the quencher. Their photocleavage ability to pBR322 plasmid DNA has been tested by gel electrophoresis and the interaction with CT DNA was detected by UV-Vis spectroscopy preliminarily.

关 键 词：卟啉 和厚朴酚 表征 光敏活性 

分 类 号：TQ460.1[化学工程—制药化工]