β-萘并冠醚卟啉的合成及光敏活性  

Synthesis and Photosensitivity of β-Arylcrown Porphyrins

作　　者：黄齐茂[1] 李清[1] 王司卫[1] 潘志权[1] 

机构地区：[1]武汉工程大学 绿色化工过程省部共建教育部重点实验室,湖北武汉430073

出　　处：《化学与生物工程》2012年第7期22-25,共4页Chemistry & Bioengineering

基　　金：国家自然科学基金资助项目(20471045);湖北省自然科学基金青年杰出人才项目(2008CDB072)

摘　　要：以2,3-二羟基萘基四苯基卟啉及其Cu(Ⅱ)配合物为原料制备了一类新型9-冠-3-四苯基卟啉,通过紫外可见吸收光谱、红外光谱、质谱、核磁共振氢谱等测试手段对冠醚卟啉进行结构表征,研究了冠醚卟啉产生单线态氧的能力、与DNA的相互作用及其对pBR322质粒DNA的切割。结果表明,冠醚卟啉具有明显的产生单线态氧的能力;与DNA的相互作用模式为外部自堆积;对DNA有较明显的切割效果。β-（2,3-Dihydroxynaphthyl-9-crown-3）-5,10,15,20-tetraphenyl porphyrins were synthesized with β-（2,3-dihydroxynaphthyl）-5,10,15-20-tetraphenyl porphyrin and its copper（ Ⅱ ） complex as raw materials,and their structures were characterized by UV-Vis, IR, MS and 1 HNMR. The producing singlet oxygen ability, the cleavage on plasmid pBR322 DNA and the interaction with DNA of the crown ether porphyrins were ex- plored. The results showed that,the crown ether porphyrins had remarkable ability of producing singlet oxygen and DNA cleavage effect,and they acted with DNA in an external self-accumulation mode.

关 键 词：冠醚 卟啉 光敏活性)DNA切割 

分 类 号：O626[理学—有机化学]