儿童药品不良反应78例报告分析  

Analysis of 78 Case Reports of Adverse Drug Reactions in Children

作　　者：王典[1] 孟庆红[1] 

机构地区：[1]中航工业哈尔滨二四二医院,黑龙江哈尔滨150066

出　　处：《航空航天医学杂志》2012年第7期782-784,共3页Journal of Aerospace medicine

摘　　要：目的:了解我院儿童药品不良反应(ADR)发生的一般规律及特点。方法:从患儿年龄、性别、给药途径、累及器官或系统及临床表现、药品种类、ADR分级等方面对我院78例儿童ADR报告,进行统计、分析。收集的78例儿童ADR报告为我院2008～2011年所发生。结果:78例ADR报告中,1～3岁儿童ADR发生率最高,性别差异不明显;静脉给药方式是引发ADR的重要途径,有50例(64.11%);ADR最常见的临床表现为皮肤及其附件损害,有45例(57.69%);引发ADR药品以头孢菌素类最多;ADR分级以轻中度为主。结论:临床应合理应用儿科药物,并重视ADR的监测及药物咨询工作,以减少或避免ADR的发生。Objective：To observe the characteristics and the general pattern of adverse drug reactions（ADRs）in children.Methods：A total of 78 ADR cases in children from 2008 to 2011 were collected from our hospital.All of these cases were analyzed statistically in clinical information such as gender and age of patients,routes of administration,organs and systems involved and clinical manifestations,drug categories,intensity of ADR.Results：Of 78 ADR cases,the incidence of ADRs was the highest in the children of 1~3 years old,and there was no significant difference in gender.The major route of administration to induce ADRs was intravenous injection in 50 cases（64.11%）,and the most common clinical manifestation of ADRs was the lesion of skin and its appendants in 45 cases（57.69%）.The most of ADRs were induced by cephalosporins,and most of the ADRs was mild and moderate.Conclusions：It is essential to pay more attention to rational use of drugs,ADRs monitoring and pharmaceutical counseling to prevent or avoid the occurrence of ADRs.

关 键 词：儿童 药品不良反应 报告 分析 

分 类 号：R969[医药卫生—药理学]