嗜酸性膀胱炎的研究进展  

Latest Research Advance of Eosinophilic Cystitis

作　　者：王培颖[1] 李黎明[2] 朱延波 

机构地区：[1]天津医科大学总医院泌尿科,天津300052 [2]天津胸科医院超声科,天津300051

出　　处：《医学综述》2012年第12期1794-1796,共3页Medical Recapitulate

基　　金：天津市卫生局科技基金(2011KZ119)

摘　　要：嗜酸性膀胱炎(EC)是一种罕见的临床病理学征象,其特征是以嗜酸粒细胞浸润为主的膀胱透壁炎症。尽管EC可能与一些致病因素有关,如变态反应、寄生虫感染、药物、膀胱损伤、膀胱肿瘤等,但其致病机制仍然不太清楚。最常见的临床表现包括尿频、血尿、排尿困难和耻骨上疼痛。膀胱镜检查和病理活检是诊断的金标准。另外,支持诊断的实验室证据包括蛋白尿、镜下血尿和外周血嗜酸粒细胞增多症。目前的治疗方案包括经尿道切除膀胱病变及药物治疗,如非甾体类抗炎药或皮质类固醇。在上述治疗下病变有复发的趋势,故长期随访是有必要的。Eosinophilic cystitis（EC）is a rare clinicopathological condition characterized by transmural inflammation of the bladder predominantly with eosinophils.The cause of EC remains unclear,although it has been associated with various etiological factors,such as allergy,parasitic infections and chemotherapeutic agents,bladder trauma,bladder tumor etc..The most common symptom complex consists of frequent urination,heamaturia,dysuria and suprapubic pain.Cystoscopy and biopsy are the gold standard for diagnosis.Additional laboratory evidence supporting the diagnosis includes proteinuria,microscopic heamaturia and peripheral eosinophilia.Current treatment modalities include transurethral resection of the bladder lesion along with non-specific medical therapy,such as non-steroidal anti-inflammatory agents or steroids.Because the lesion tends to recur in spite of the above therapy,long-term follow-up is necessary.

关 键 词：嗜酸性膀胱炎 嗜酸粒细胞增多症 治疗 

分 类 号：R694.3[医药卫生—泌尿科学]