C肽在血管平滑肌细胞增生和迁移中的作用  

Effect of C-peptide on the Migration and Proliferation of VSMCs

作　　者：余小平[1,2] 尤文俊[1,2] 

机构地区：[1]福建医科大学第一临床医学院 [2]厦门市第一医院心脏外科,福州350002

出　　处：《医学综述》2012年第12期1830-1832,共3页Medical Recapitulate

摘　　要：C肽是胰岛B细胞分泌的,是胰岛素原转化成胰岛素的副产物。长期以来,一直认为C肽无生物活性,在临床上一直作为判断B细胞功能的指标。随着近年来的研究进展,多项基础和临床研究都显示C肽水平与心血管、神经功能密切相关,从而日益受到重视。现从C肽对血管平滑肌细胞增生与迁移的作用以及可能的信号通路和相关基因等方面的研究进展进行综述。C-peptide is secreted by pancreatic B cell and cleaved from the processing of proinsulin to insulin.For decades,studies reported no biological function of C-peptide and it only served as an indicator of pancreatic B cell function in the clinical.But recently,a number of basic and clinical investigators have revealed that the level of C-peptide is closely related to the cardiovascular and neurological function,which is being paid increasing attention.Here is to make a review on the current research progress of C-peptide effect on vascular smooth muscle cells（VSMCs）migration and proliferation and possible signal pathways and the related genes.

关 键 词：血管平滑肌细胞 C肽 增生 迁移 

分 类 号：R587.1[医药卫生—内分泌] R977.15[医药卫生—内科学]