慢性阻塞性肺疾病是加速的肺老化疾病  

Chronic Obstructive Pulmonary Disease is the Accelerated Aging of Lung

作　　者：何伊里[1] 何志义[1] 

机构地区：[1]广西医科大学,南宁530021

出　　处：《医学综述》2012年第13期2064-2066,共3页Medical Recapitulate

摘　　要：慢性阻塞性肺疾病(COPD)是一种以在小呼吸道和肺实质中渐进性的炎性反应以及不完全可逆性气流受限为特征的疾病。从病理方面看,它导致了呼吸道壁结构重构、管腔狭窄,引起气流受限等功能改变。肺部的老化则是一个必然的不可逆转的漫长的渐进的过程,从生理方面看,人体发育至25～30岁成熟,此后开始衰退,最终也导致呼吸道结构的改变和功能的破坏。COPD与肺老化殊途同归。而由于炎性反应等原因,COPD的过程可以看作是加速的肺老化过程。Chronic obstructive pulmonary disease（COPD）is a disease featured with progressive inflammatory response in the small airways and lung parenchyma and incomplete reversible airflow limitation.From the pathological aspect,it leads to airway wall remodeling,stenosis,and other functional changes caused by airflow limitation.Aging of the lungs is an inevitable and irreversible long evolutionary process,from the physiological perspective,human development reach mature at the age of 25 to 30 years,then the decline begins,which eventually leads to changes in airway structure and function damage.COPD and lung aging lead to the same result,and due to the inflammation and other reasons,COPD can be seen as an accelerated lung aging process.

关 键 词：慢性阻塞性肺疾病 炎性反应 肺老化 加速 

分 类 号：R563[医药卫生—呼吸系统]