精子形态与体外受精中受精率的关系  

Influence of sperm morphology on in vitro fertilization rates

作　　者：潘家坪[1] 陈智勤[1] 王羽[1] 尹萍[1] 梁珊珊[1] 阮井玲[1] 李昆明[1] 滕晓明[1] 

机构地区：[1]同济大学附属第一妇婴保健院生殖医学中心,上海200040

出　　处：《诊断学理论与实践》2012年第3期249-251,共3页Journal of Diagnostics Concepts & Practice

摘　　要：目的:探讨精子形态对体外受精受精率的影响。方法:回顾总结2010年我中心进行常规体外受精(IVF)治疗的561对不育夫妇,按WHO推荐改良巴氏染色方法对精子进行形态学检查,按精子正常形态分为<4%组、4%～9%组、9.5%～14%组和>14%组,分别统计各组精子进行IVF后的受精率。结果:IVF中总受精率为71.00%,精子正常形态<4%组、4%～9%组、9.5%～14%组和>14%组的受精率分别为53.19%、71.33%、71.30%、72.27%。正常形态<4%各组与≥4%各组间的受精率差异有统计学意义(P<0.05)。结论:精子形态对IVF中的受精率有一定影响,精子正常形态低于4%时明显影响IVF的受精率。因此,精子形态分析结果可成为临床上选择IVF还是卵细胞质内单精子注射(ICSI)治疗的参考依据,从而避免一些IVF失败。Objective To explore the influence of sperm morphology on fertilization rate during in vitro fertilization.Methods Five hundred and sixty-one couples undergone IVF treatment in 2010 were recruited in this study.They were divided into four groups according to husband＇s sperm morphology： normal spermatozoa morphology 4%,4%-9%,9.5%-14%,and 14%.Results The overall fertilization rate was 71.00%.The fertilization rates of the normal spermatozoa morphology 4%,4%-9%,9.5%-14% and 14% groups were 53.19%,71.33%,71.30% and 72.27%,respectively.The fertilization rate in normal spermatozoa morphology 4% group was significantly lower than that in the other 3 groups（P0.05）.Conclusions Sperm morphology is related to the fertilization rate in IVF.The normal spermatozoa morphology 4% significantly predicts the lower fertilization rate.Therefore,sperm morphology analysis can provide evidence for the clinicians whether to choose IVF or ICSI（intra-cytoplasmic sperm injection）,and thus can avoid some of the fertilization failure.

关 键 词：精子形态学检查 体外受精 受精率 

分 类 号：R715.2[医药卫生—妇产科学]