染发剂与骨髓增生异常综合征关系的病例-对照研究  

Case control study on relationship between hair dye use and myeloid dysplastic syndrome

作　　者：张耀[1] 孙璐 张曦[1] 肖超[1] 常春康[1] 李晓[1] 

机构地区：[1]上海交通大学附属第六人民医院血液科,上海200233 [2]上海市黄埔区中心医院血液科,上海200002

出　　处：《诊断学理论与实践》2012年第3期269-272,共4页Journal of Diagnostics Concepts & Practice

基　　金：上海交通大学医工交叉项目资助:染发与MDS相关性(YC2010MS42)

摘　　要：探讨骨髓增生异常综合征(myelodysplastic syndrome,MDS)的危险因素。方法 :对我院102例初诊的MDS患者和102名性别、年龄匹配的健康对照者进行1∶1配对的病例-对照研究,调查受试者的一般情况、毒物接触史、使用抗肿瘤药物史、染发史、放射线接触史和肿瘤家族史等,并应用Logistic回归对资料进行统计分析,估计人群归因危险度。结果:Logistic回归分析显示,染发剂的种类、使用频率和年限是MDS发生的危险因素,其OR值分别为2.36、2.23和2.11,调整归因危险度分别为19.80%、17.12%和15.64%,综合归因危险度为30.63%。结论:染发剂的使用与MDS的发生有关。Objective To study the risk factors of myeloid dysplastic syndrome（MDS）.Methods A matched case-control study consisting of 102 newly diagnosed MDS patients and 102 gender and age-matched controls were performed to explore the risk factors for MDS.Sex,age,history of toxin exposure,use of antitumor drugs,use of hair dye,radiation exposure and cancer family history were analyzed by conditional logistic regression analysis.Results Type of hair dye,duration and frequency of hair dying were the risk factors for MDS.The OR values were 2.36,2.23 and 2.11,respectively.Adjusted attributable risks were 19.80%,17.12% and 15.64%,respectively.Overall attributable risk was 30.63%.Conclusions Use of hair dye might have relation with MDS.

关 键 词：染发剂 骨髓增生异常综合征 病例-对照研究 LOGISTIC回归 

分 类 号：R551.3[医药卫生—血液循环系统疾病]