学龄前哮喘儿童体外过敏原筛查与脉冲振荡肺功能检测  

In vitro screening of allergen and lung function tests with impulse oscillometry in preschool children with asthma

作　　者：郁志伟[1] 谢娟娟[1] 钱俊[1] 潘剑蓉[1] 张晓娟[1] 项红霞[1] 

机构地区：[1]南京医科大学附属无锡市人民医院儿呼吸科,江苏省214023

出　　处：《江苏医药》2012年第14期1633-1636,共4页Jiangsu Medical Journal

基　　金：无锡市社会发展计划项目(CSZ00853)

摘　　要：目的研究体外过敏原筛查与脉冲振荡肺功能检测在学龄前哮喘儿童中的应用价值。方法 120例学龄前儿童分为哮喘急性发作组(A组,44例),哮喘非急性发作组(B组,41例)和正常对照组(C组,35例)。应用免疫检测分析仪筛查血吸入过敏原、食入过敏原,检测尘螨特异性IgE、血总IgE和血嗜酸性粒细胞阳离子蛋白(ECP)。采用脉冲振荡肺功能测定肺功能参数呼吸总阻抗(Zrs)、总呼吸黏性阻力(R5)、中心气道黏性阻力(R20)、周边气道黏性阻力(R5-R20)、周边弹性阻力(X5)和共振频率(Fres)。结果 A、B组吸入过敏原、食入过敏原阳性率、总IgE水平差异无统计学意义(P>0.05);B组血ECP水平、Zrs、R5、R20、R5-R20、Fres较A组低(P<0.05)。B组Zrs、R5、R5-R20、Fres与血ECP呈正相关(P<0.05),R20与血ECP不相关(P>0.05)。结论检测血过敏原、血ECP、脉冲振荡肺功能有助于了解学龄前哮喘儿童气道炎症变化及气道阻塞情况。Objective To study the role of in vitro screening of allergen and lung function tests with impulse oscillometry in preschool children with asthma. Methods Ohe hundred and twenty preschool children were divided into three groups of A（44 cases with acute asthma）, B（41 cases with chronic asthma） and C（35 healthy controls）. Inhaled allergen, food allergen and mitc-specifie IgE were determined by Pharmacia UniCAP System. The serum eosinophil cationic protein（ECP） and total IgE were measured as well. Lung function was measured by impulse oscillometry technique. The respiratory total impedance（Zrs）, airway resistance at 5 Hz（RS）, airway resistance at 20 nz （R20）, subtracting R5 from R20 （R5-R20）, reactance at 5 Hz （X5） and resonant frequency （Fres） were evaluated. Results Positive findings of inhaled allergen, food allergen and total IgE levels in group A were not significantly different from those in group B（P〉0. 05）. Serum ECP hwels, Zrs, RS, R20, R5-R20 and Fres in group B were lower than those in group A （ P〈0. 05 ）. Serum ECP levels were positively correlated with Zrs,RS, R5-R20 and Fres（P〈0. 05）, but not correlated with R20 in group B （P〉0. 05）. Conclusion The in vitro screening of allergen, detecting serum ECP and examing lung functions with impulse oscillometry are helpful in evaluating the airway inflammation and obstruction in preschool children with asthma.

关 键 词：哮喘 过敏原 脉冲振荡肺功能检测 嗜酸性粒细胞阳离子蛋白 

分 类 号：R725[医药卫生—儿科]