2型糖尿病伴冠心病患者血清胱抑素C水平及其意义  

Plasma cystatin C in coronary heart disease complicated with type 2 diabetes mellitus

作　　者：赵祥峰[1] 杜晓晖[1] 王志权[1] 

机构地区：[1]解放军第161医院心血管内分泌科,武汉430010

出　　处：《临床心血管病杂志》2012年第7期539-541,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨血清胱抑素C(Cys C)水平与2型糖尿病伴冠心病的关系。方法:收集40例单纯2型糖尿病患者(DM组)、120例2型糖尿病伴冠心病(CHD)患者(DM+CHD组)及40例健康者(对照组)的血清。分别测定基础代谢率、血压、血脂、血清糖化血红蛋白及Cys C水平。结果:血清Cys C水平在DM组[(1.58±0.78)mg/L]、DM+CHD组[(2.12±0.94)mg/L]较对照组[(0.82±0.23)mg/L]明显升高,差异有统计学意义(P<0.01),DM+CHD组明显高于DM组(P<0.05)。冠状动脉狭窄支数越多,血清Cys C水平越高。结论:2型糖尿病伴CHD患者的血清Cys C水平增高,且随冠状动脉狭窄病变支数的相应增加呈增高趋势,提示Cys C在2型糖尿病伴CHD的发生发展中起一定作用。To investigate the effect of cystatin C （Cys C） on patients with type 2 diabetes mellitus （DM） and coronary heart disease （CHD）. Method： The plasma from 40 patients with DM without CHD （DM group）, 120 patients with DM and CHD （DM＋CHD group）, and 40 healthy person（control group） were collect-ed. The basic metabolism index, blood pressure, plasma level of lipid, glycosylated hemoglobin （HbAlc） and Cys C were measured. Result：The plasma levels of Cys C in DM group [（1.58±0.78）mg/L] and DM＋CHD group [（2. 12±0.94）mg/L] were significantly higher than that in control group [（0,. 82±0.23）mg/L], and plasma Cys C in DM＋CHD group was significantly higher than that of DM group. The more stenosed coronary, the higher level of plasma Cys C was. Conclusion：The levels of plasma Cys C in patients with DM and CHD were increased compared with that of DM group, and plasma Cys C was increased depending on the degree of coronary stenosis.

关 键 词：冠心病 2型糖尿病 胱抑素C 

分 类 号：R541.4[医药卫生—心血管疾病]