科素亚对高血压左心室肥厚患者血清IGF-1和BNP的影响  

The clinical study on IGF-1 and BNP detection on patients with hypertension with left ventricular hypertrophy treated by Losartan

作　　者：王俊谊[1] 

机构地区：[1]井冈山大学附属医院心内科,江西吉安343000

出　　处：《中国现代医生》2012年第19期58-59,共2页China Modern Doctor

摘　　要：目的研究高血压左心室肥厚患者应用科素亚的治疗效果,关注治疗后血清中胰岛素样生长因子1(IGF-1)和血浆脑钠肽(BNP)浓度的变化,以期为临床工作提供支持。方法收集我院确诊的98例高血压左心室肥厚的患者,按入院的先后分为两组,观察组和对照组各49例,对照组应用常规治疗和硝苯地平,观察组患者在对照组治疗的基础上加用科素亚,观察其治疗后超声心动功能的差异,及治疗后两组血清中IGF-1和BNP的差异。结果治疗后观察组与对照组IVST、LVPWT和LVMI的比较,差异均有统计学意义;观察组与对照组治疗后血清中IGF-1和BNP的比较差异均有统计学意义。结论高血压左心室肥厚患者应用科素亚的治疗效果理想,且能有效下调血清中IGF-1和BNP的表达,临床值得推广应用。Objective To study the curative effect, IGF-I and BNP expressions on hypertension with left ventricular hy- pertrophy by Losartan. Methods Ninety-eight cases were divided into two groups. The control group（49 cases） was treated by routine and nifedipine. The observation group（49 cases） was added by Losartan. The IGF-1 and BNP of serum were de- tected in the two groups after treatment. Results The eurative effect was better in the observation than in the control group. The expressions of IGF-1 and BNP were lower in the observation group than in the control group. Conclusion The treatment of Losartan is satisfied,can decreased the expressions with IGF-1 and BNP, is worthy of being recommended in patients with hypertension with left ventricular hypertrophy.

关 键 词：科素亚 高血压 左心室肥厚 IGF-1 BNP 

分 类 号：R542.22[医药卫生—心血管疾病]