羟苄羟麻黄碱治疗先兆早产的疗效观察  

Clinical observation of 112 cases with hydroxy benzyl hydroxy ephedrine treatment of threatened premature

作　　者：马擘[1] 

机构地区：[1]天津市中心妇产科医院妇产科,天津300100

出　　处：《中国现代医生》2012年第20期148-149,共2页China Modern Doctor

摘　　要：目的探讨盐酸羟苄羟麻黄碱治疗先兆早产的疗效。方法将112例患者随机分为治疗组(55例)和对照组(57例),治疗组给予羟苄羟麻黄碱,对照组给予硫酸镁。观察两组有效抑制宫缩的显效时间、延长孕期、累积用药时间及药物的副反应。并在用药过程中观察用药反应。结果治疗组与对照组比较:宫缩抑制显效时间(2.43±0.39)h vs(6.15±0.87)h、累积用药时间(8.10±1.14)d vs.(13.06±3.46)d、延长孕期时间(25.71±5.24)d vs(15.32±4.10)d、早产发生率[10.91(6/55)vs 33.33(19/57),差异有统计学意义(P<0.05)。结论合理使用盐酸羟苄羟麻黄碱可以延长孕妇妊娠周数,提高早产儿存活率及生存质量。Objective To investigate the effect of hydroxyl benzyl ephedrine in the treatment of threatened premature. Methods The 112 patients randomLy divided into treatment group（55 patients） and control group（57） patients. The treatment group was treated with benzyl hydroxy-ephedrine, the control group was given magnesium sulfate, The markedly inhibited uterine contraction time,the extension of pregnancy,the cumulative medication time and drug toxicity were ob- served in the two groups. Results A comparison between treatment group and control group showed the onset time of the inhibited uterine contraction was （2.43＋0.39）h vs （6.15＋0.87）h,the cumulative medication time was （8.10＋1.14）d vs. （ 13.06 ＋ 3.46 ） d, the extended pregnancy time was （25.71 ＋5.24 ） d vs. （ 15.32 ＋4.10 ） d and the incidence of prematurity was 10.91 （6/55）vs. 33.33 （ 19/57 ） （all P 〈 0.05）. Conclusion The rational using of Hydroxyl hydroxyl benzyl ephednne may be extended a few weeks of pregnancy and improve the survival rate of premature infants and the quality of life.

关 键 词：盐酸羟苄羟麻黄碱 硫酸镁 先兆早产 

分 类 号：R271.9[医药卫生—中西医结合]