药物中间体4-氯苯基苄基酮的合成  

Study of the Synthesis of Pharmaceutical Intermediate 4-Chlorophenylbenzylketone

作　　者：王昕宇[1] 徐崇福[1] 陈颖[1] 张杜娟[1] 李艺林[1] 

机构地区：[1]常州大学石油化工学院,江苏常州213164

出　　处：《常州大学学报（自然科学版）》2012年第2期31-34,共4页Journal of Changzhou University：Natural Science Edition

摘　　要：以氯化苄和对氯苯甲醛为原料,通过格氏法合成4-氯苯基苄基醇,进一步经硅胶负载氯铬酸吡啶(PCC)氧化为成4-氯苯基苄基酮。总产率为75.0%。探讨多种因素对收率的影响,获得控制反应过程的最佳参数。通过IR、1 H NMR、13 C NMR对产物的结构进行了分析表征。4--chlorophenylbenzylmethanol was synthesized via Grignard method using benzyl chloride and p--chlorobenzaldehyde as starting materials, subsequent oxidation by silica gel loaded pyridinium chlorodi-chromate afforded 4--chlorophenylbenzylketone with 75% overall yield. Various factors on the yield of products were explored, and the optimal parameters for controlling reaction processes were obtained. The molecular structures of the products were characterized using infrared, 1H and 1℃ nuclear magnetic reso-nance spectroscopy.

关 键 词：4-氯苯基苄基醇 4-氯苯基苄基酮 格氏反应 氧化 

分 类 号：O625.42[理学—有机化学]