脑源性神经营养因子基因Val66Met位点多态性与大学生创造力、人格特质的相关性研究  

Association study of val66Met functional polymorphism in brain-derived neurotrophic factor with creativi- ty and personality traits of college students

作　　者：李舍[1] 曹国昌[1] 张培哲[1] 冯田田[1] 龚平原[1] 

机构地区：[1]河南科技大学药理学与医学分子生物学实验室,洛阳471003

出　　处：《中华行为医学与脑科学杂志》2012年第7期653-655,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：河南科技大学博士科研启动基金;河南科技大学SRTP项目（2011164,2011245）

摘　　要：目的在健康大学生人群样本中探讨脑源性神经营养因子（BDNF）基因内重要的功能性多态位点Val66Met与人类创造力和人格特质的相关性。方法采用威廉斯创造力量表和艾森克人格量表测量随机选取的830名大学新生（男性272人、女性558）的创造力和人格特质，分析了Val66Met多态性功能位点与4个创造力因子和4个人格特质因子的相关性。结果Val66Met多态性功能位点与创造力的好奇性因子之间有显著相关性旷=0．519，P=0．036），并且Val等位基因的拷贝数与好奇性呈正相关，Vale-6Val基因型个体表现出的好奇性最强[（31．924±4．010）分]，Met66Met基因型个体的好奇性最差[（30．889±3．478）分]；Val66Met多态性功能位点在本研究中与四个人格特质因子之间均无显著相关性（P〉0．05）；内外向人格特质因子和Val66Met多态性功能位点之间的交互作用对好奇性因子的影响不显著（P=0．747）。结论本研究提示BDNF基因内的多态位点Val66Met在该人群中对人类创造力有显著影响，对人格特质无显著影响。Objective To study the associations of Va166Met functional polymorphism in brain-derived neurotrophic factor （BDNF） with creativity and personality traits in a healthy college student population. Method The creativity performance and personality traits of the 830 healthy college students （272 males and 558 females） were assessed with Williams Creativity Scale （CAP） and adult Eysenck Personality Questionnaire （EPQ） ,then study was performed on the association Va166Met in BDNF with creativity and personality traitor. Re- suits The results indicated that Va166Met was significantly associated with the curiosity of CAP （F= 0. 519 , P= 0. 036）. The numbers of Val allele showed a positive correlation to the performance of curiosity. Va166Val geno- type individuals had the best performance （31. 924 ±4. 010） while the Met66Met ones showed the worst pe：fform- ance（30. 889 ± 3. 478 ）. However, the association of Va166Met with the personality traits of EPQ was not signifi- cant in the study （P 〉 0.05 ）. Furthermore, there was no a significant effect of the interaction between the genetic variant and Extraversion/Introversion on the curiosity of CAP （P = 0. 747 ）. Conclusion The present stud,; sug- gests that Va166Met in BDNF contributes to creativity,but not to personality traits in the population.

关 键 词：脑源性神经营养因子 创造力 人格特质 

分 类 号：B845[哲学宗教—心理学]