乙型肝炎疫苗2针免疫程序的研究进展  

Two dose vaccination schedule of hepatitis B vaccine

作　　者：李津[1,2] 沈永才 庄辉[1] 

机构地区：[1]北京大学医学部基础医学院病原生物学系和感染病中心,北京100191 [2]北京天坛生物制品股份有限公司,北京100024

出　　处：《中国病毒病杂志》2012年第4期241-244,共4页Chinese Journal of Viral Diseases

基　　金：国家"十二五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10002002)

摘　　要：随着疫苗免疫计划的扩大和接种疫苗种类的增多,免疫注射的总接种针次增加,乙型肝炎（乙肝）疫苗免疫程序接种针次较多的不足逐渐凸显。美国18～49岁的乙肝高危人群和普通人群中,常规3针乙肝疫苗免疫的全程接种率仅为41.8%和31.2%[1]。The 3-dose immunization regimen of hepatitis B（HB） vaccine at the 0,1 and 6 months is the most common and effective approach to control the transmission of hepatitis B virus（HBV）,and plays a crucial role for reducing HBV infections among people.However,the completion rate is low due to factors like low compliance,relatively high cost and the 6-month long duration.Studies of a novel 2-dose vaccination schedule showed similar effects of immune response comparing to the standard 3-dose regimen.In this review,we summarize the recent development of the 2-dose HBV vaccine regimen and at the same time,we also discuss the immune mechanism,prophylactic efficacy and cost-effectiveness of the 2-dose HBV vaccination schedule.

关 键 词：病毒性肝炎 乙型 乙型肝炎病毒 疫苗 预防 

分 类 号：R186[医药卫生—流行病学]