寻常型银屑病中医基本证候与疾病分期及病情的相关性探讨  

Correlation of Elementary Traditional Chinese Medical Syndromes with Severity and Stages of Psoriasis Vulgaris

作　　者：闫玉红 卢传坚 姚丹霓 杜菡 李华莉 

机构地区：[1]广州中医药大学第二附属医院皮肤科,广东广州510120

出　　处：《广州中医药大学学报》2012年第4期358-362,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省自然科学基金课题(编号:S2011040003130);广东省财政厅课题(编号:2011KT1887);广东省中医院中医特色与优势临床研究专项(编号:2011KT374)

摘　　要：【目的】了解银屑病中医基本证候在人群中的分布,探讨银屑病中医基本证候与疾病分期及病情严重程度的相关性。【方法】采用横断面调查的流行病学研究方法,纳入280例寻常型银屑病患者进行问卷调查,运用统计学方法分析寻常型银屑病基本证候与疾病分期及各项病情严重程度指标的相关性。【结果】(1)寻常型银屑病患者中医基本证候分布依次为:血瘀证(70.3%)>血燥证(17.3%)>风热证(12.4%);疾病分期依次为:稳定期(57.5%)>进行期(26.9%)>消退期(15.7%)。(2)中医基本证候与疾病分期的关系:风热证在进行期中所占比例较大,血瘀证和血燥证在静止期中所占比例较大。风热证与进行期相关,血瘀证与稳定期相关,消退期与血燥证相关。(3)中医基本证候与各项病情评判指标的关系:不同中医证型间银屑病的疾病严重程度具有显著差异(P<0.01),PASI评分风热证>血瘀证>血燥证;瘙痒评分风热证>血燥证>血瘀证。回归分析发现:躯干部的PASI评分和瘙痒评分对3种证型的影响程度不同,与血燥证和风热证正相关,与血瘀证负相关;年龄分段与血燥证负相关。【结论】血瘀证与稳定期的病人在本次研究中所占比例最高。不同中医证型间银屑病的疾病严重程度存在差异,证型与银屑病分期可能有对应关系:风热证与进行期相关,血瘀证与稳定期相关,消退期与血燥证相关。Objective To investigate the distribution of elementary traditional Chinese medical syndromes in psoriasis vulgaris patients, and to explore the correlation of elementary syndromes with the severity and stages of psoriasis vulgaris. Methods A cross-sectional study was carried out in 280 psoriasis vulgaris patients. Questionnaire investigation was performed, and the collected data was used for the analysis of the correlation of elementary syndromes with the severity and stages of psoriasis vulgaris. Results （ 1 ） The elementary syndromes of psoriasis vulgaris were blood-stasis syndrome （70.3%）, blood-dryness syndrome （ 17. 3% ） and wind-heat syndrome （12.4%） , and they were in decreasing sequence. The stages of psoriasis vulgaris covered stable stage （57.5%）, active stage （26.9%） and regressive stage （ 15.7% ）. （2） The proportions of three syndromes varied with the stages of psoriasis vulgaris： wind-heat syndrome was dominated in the active stage, and blooddryness syndrome and blood-stasis syndrome were predominant in the stable stage. The results of correspondence analysis showed that wind-heat syndrome was correlated with the active stage, blood-stasis syndrome was correlated with the stable stage, and blood-dryness syndrome was correlated with the regressive stage. （3） The severity of psoriasis vulgaris varied in three syndromes （P 〈 0.01 ） ： PASI score was the highest in wind-heat syndrome, higher in blood-stasis syndrome, and high in blood-dryness syndrome, and pruritus score was the highest in wind-heat syndrome, higher in blood-dryness syndrome and high in blood-stasis syndrome. The results of regression analysis showed that body PASI score and pruritus score were positively correlated with blood-dryness syndrome and wind- heat syndrome, and were negatively correlated with blood-stasis syndrome. Age groups were negatively correlated with blood-dryness syndrome. Conclusion Blood-stasis syndrome and stable stage are predominant in psoriasis vulgaris patients of th

关 键 词：寻常型银屑病 中医证候 疾病分期 病情 

分 类 号：R275.9[医药卫生—中西医结合]