以牡蛎壳为钙源的L-天冬氨酸螯合钙的合成及其生物利用度研究  

Synthesis of L-aspartate Chelating Calcium with Oysters as Calcium Source and Investigation of Its Bioavailability

作　　者：邵江娟[1] 王唯[1] 陈斌寅[1] 陈韬[1] 陈建伟[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210046

出　　处：《南京中医药大学学报》2012年第4期371-373,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家"十一五"科技支撑计划子课题(2006BAI09B06-04);江苏高校优势学科建设工程资助项目(ysxk-2010);江苏省普通高校研究生科研创新计划项目(2011-789);南京中医药大学青年自然科学基金项目(11XZR14)

摘　　要：目的探究以牡蛎壳为钙源制备L-天冬氨酸螯合钙的合成路线,并分析产品的生物利用度。方法制定合成路线,并按照4因素3水平进行正交试验,得到产率最高的反应条件;对最优反应条件下生成的产物进行生物利用度研究,并与葡萄糖酸钙进行对照试验。结果以牡蛎壳为钙源与酸性氨基酸L-天冬氨酸直接作用合成了L-天冬氨酸螯合钙,最合适的pH为3、摩尔配比(牡蛎∶L-天冬氨酸)为1∶2、反应温度为80℃、反应时间1h;产品具有较高的生物利用度。结论以牡蛎壳为钙源的天冬氨酸螯合钙的合成工艺可行,产率较高,产品的生物利用度较葡萄糖酸钙高。OBJECTIVE To explore a synthetic route for L-aspartate chelated calcium with oysters as the calcium source and analyze the bioavailability of this product. METHODS The synthetic route was found out by searching and reviewing literatures, conducting orthogonal test according to ＂four factors of three level＂, getting the highest productivity reaction condition, studying the bioavailability of this product under the most optimized reaction condition, and making check test with calcium gluconate. RESULTS L-aspartate chelated calcium was synthetized by oysters as the calcium source and acidic amino acid L-as partate . The most appropriate condition is pH： 3, molar ratio（oyster powder ： L-aspartate） 1 ： 2, reaction temperature 80 ℃, reaction time 1 h. The product had relativelY high bioavailability. CONCLUSION Synthetic route for L-aspartate chelated calcium with oysters as the calcium source is feasible with relatively high productivity and its bioavailability is higher than that of calcium gluconate.

关 键 词：牡蛎 L-天冬氨酸 螯合钙 生物利用度 

分 类 号：R285.5[医药卫生—中药学]