注射用夫西地酸钠与3种常用输液的配伍稳定性  

Compatibility and stability of sodium fusidate for injection with three common clinical infusion fluids

作　　者：吴伟明[1] 陈丽佳[1] 王军[1] 王增寿[1] 藤泽清[2] 

机构地区：[1]温州医学院附属第二医院药剂科,温州325027 [2]温州医学院药学院,温州325027

出　　处：《中国临床药学杂志》2012年第4期234-236,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的考察注射用夫西地酸钠在0.9%氯化钠注射剂、5%葡萄糖注射剂及5%转化糖注射剂中的配伍稳定性。方法将注射用夫西地酸钠按临床常规用药剂量加入3种输液中,分别于25、37℃不避光条件下放置8 h,用HPLC法测定配伍后不同时间点配伍液中药物的含量,观察外观性状并测定其pH值和不溶性微粒。结果 25C时,夫西地酸钠在3种溶媒中的含量在8 h内无明显变化;37℃时,夫西地酸钠在3种溶媒中的含量在4 h内无明显变化,但8 h后明显下降(浓度下降接近或超过10%);两种温度下8 h内配伍剂的外观、pH值和不溶性微粒均无明显变化。结论注射用夫西地酸钠除了可与0.9%氯化钠注射剂、5%葡萄糖注射剂配伍外,还可与5%转化糖注射剂配伍;并且与3种输液配伍后,应置阴凉处储存,于8 h内输注完毕。AIM To investigate the compatible stability of sodium fusidate for injection in 0.9 % sodium chloride injection, 5% glucose injection and 5% invert sugar injection. METHODS A clinical routine dose of sodium fusidate for injection was added to each of the three infusion fluids, and the mixtures were kept at 25℃and 37℃ for 8 h with light. The contents of sodium fusidate in the fluids was determined at different time points by HPLC. The outward apear- ance , pH values and insoluble particles were observed as well. RESULTS The content of sodium fusidate in three infu- sion fluids was shown to have undergone no apparent changes at 25℃ within 8 h. But at 37℃, the content of sodium fusidate in three infusion fluids was shown a reduction by about 10% within 8 h. The outward appearance , pH values and insoluble particles in three infusion fluids were shown to have undergone no apparent changes at 25℃ and 37℃ with- in 8 h. CONCLUSION Sodium fusidate for injection can be compatible with 0.9% sodium chloride injection, 5% glu- cose injection and 5 % invert sugar injection, which should be stored in a shady and cool place and injected within 8 h.

关 键 词：夫西地酸钠 高效液相色谱法 配伍 稳定性 

分 类 号：R472[医药卫生—护理学]