小陷胸颗粒的制备  

Preparation of Xiaoxianxiong Granules

作　　者：罗国平[1] 孟会宁 冯锁民[1] 马远涛[1] 赵宁[1] 

机构地区：[1]西安医学院药学院,陕西西安710021 [2]山东步长医药销售有限公司,山东菏泽274418

出　　处：《应用化工》2012年第7期1213-1215,共3页Applied Chemical Industry

基　　金：2011年陕西省教育厅专项科研计划项目(11JK0696)

摘　　要：用75%乙醇回流提取药材有效成分,制备小陷胸颗粒,以颗粒的成型性和溶化性能为指标,考察了糊精、蔗糖的比例以及润湿剂的浓度。结果表明,药材提取的最佳条件为:加5倍量乙醇,提取3次,每次1.5 h;干膏∶糊精∶蔗糖=2∶1∶1,润湿剂为85%的乙醇,颗粒的成型率达85%以上。采用选定的提取条件和制剂工艺制备的颗粒,其成型性和溶化性均较好。Preparation of Xiaoxianxiong Granules with the ＇active ingredient of medicinal materials extraction by 75% ethanol. The proportional quantities of dextrin and cane sugar in Granules and centration of wetting agent were investigated, the moldability and dissolving property of Granules refluxed the con- were re- garded as the detection index. Results showed that the optimum extraction was as follows：soaking in five times amount of ethanol, extracting three times, every time for 1.5 h. The proportion of dry extraction, dex- trin and cane sugar was 2 ： 1 ： 1, wetting agent was 85% ethanol. Forming ratio was much more than 85%. The moldability and dissolving property of Granules which was prepared by selected extracting con- dition and preparation technology was preferable.

关 键 词：小陷胸颗粒 提取 制备 正交设计 

分 类 号：TQ46[化学工程—制药化工] R944.27[医药卫生—药剂学]