一锅环合偶联法合成N-叔丁氧羰基-3-苯甲基-2,3-二氢吲哚  

The synthesis and characterization of N-(tert-butoxycarbonyl)-3-phenylmethyl-2,3-dihydroindoline by one-pot cycloaddition-coupling reaction

作　　者：欧阳红霞[1] 张小林[1,2] 丁永红[1] 孙戊辰[1] 

机构地区：[1]南昌大学抚州医学分院,江西抚州344000 [2]南昌大学环境与化学工程学院,江西南昌330031

出　　处：《应用化工》2012年第7期1288-1290,共3页Applied Chemical Industry

摘　　要：以邻溴苯胺为原料,经过氨基酰化反应和烯丙基反应得到中间体N-烯丙基-N-叔丁氧羰基邻溴苯胺,中间体在醋酸钯和三苯基膦催化下,与苯硼酸发生环合偶联反应,得到目标产物N-叔丁氧羰基-3-苯甲基-2,3-二氢吲哚,总收率为37%。采用IR,1H NMR,13C NMR和MS对产品进行表征。N-（ tert-butoxycarbonyl ） -3-phenylmethyl-2,3-dihydroindoline was prepared from 2-bromoani- line via aeylation, allyalation and cycloaddition-coupling reaction by employing phenylboronic acid as ani- on transfer reagent in the catalysis of Pd（OAc）2 and PPh3. The total yield is 37%. The compound was confirmed by IR,1H NMR,13C NMR and MS.

关 键 词：二氢吲哚 环合偶联 合成 苯硼酸 

分 类 号：TQ246.3[化学工程—有机化工]