氟康唑治疗深部真菌病临床疗效与安全性分析  

A Comparison on Fungicidal Efficacy and Safety of Domestic and Imported Fluconazole Injection

作　　者：殷凯生[1] 吴振国[2] 范洵楠 朱晓莉[4] 解卫平[1] 包志达 戴玲娟 张祖贻[4] 

机构地区：[1]南京医科大学第一附属医院呼吸科,南京210029 [2]解放军南京军区南京总医院老年医学科,南京210002 [3]南京市鼓楼医院传染科,南京210008 [4]南京铁道医学院附属医院呼吸科,南京210009

出　　处：《南京医科大学学报（自然科学版）》2000年第1期31-34,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的　比较国产与进口氟康唑注射剂治疗深部真菌病临床疗效与安全性。方法　在 170例深部真菌病患者中作了前瞻性多中心研究。结果　试验组 (T组 )与对照组 (C组 )临床综合疗效痊愈率 (5 0 .9%和 5 0 .9% )、有效率 (83.6 %和89.1% )、致病菌株清除率 (83.9%和 89.1% )和不良反应发生率 (8.9%和 9.1% )之间差异均无显著性 (P>0 .0 5 )。结论　国产与进口氟康唑注射液都是安全、有效的抗真菌药物。Objective To compare the clinical efficacy and safety of domestic and imported fluconazole injections in treating patients with deep fungal infections. [WT5,5”HZ]Methods A prospective multicentre study in 170 cases of deep fungal infections was performed. [WT5,5”HZ]Results There were no statistically significant differences in recovery rates (50.9% v 50.9%), effective rates (83.6% v 89.1%), clearance rates of fungals (83.9% v 89.1%), and side effect rates (8.9% v 9.1%) between test group and control group. Conclusion Both domestic and imported fluconazole injections are safe and effective drugs for treating deep fungal infections.

关 键 词：深部真菌病 氟康唑 真菌感染 药物疗法 疗效 

分 类 号：R756.605[医药卫生—皮肤病学与性病学] R986[医药卫生—临床医学]