肥胖与多囊卵巢综合征的相关分析  

Analysis of Obesity and Polycystic Ovary Syndrome

作　　者：张争[1] 张学红[1] 

机构地区：[1]兰州大学第一医院生殖医学研究中心,730000

出　　处：《国际生殖健康／计划生育杂志》2012年第4期316-318,共3页Journal of International Reproductive Health/Family Planning

摘　　要：多囊卵巢综合征(PCOS)是育龄妇女最常见的临床表现高度异质性的内分泌、代谢疾病,是无排卵性不孕的主要原因之一,发病率占育龄妇女的5%～10%。肥胖与PCOS存在紧密联系。PCOS患者中,约50%存在超重或肥胖,其中大部分表现为腹型肥胖。肥胖与一系列代谢紊乱有关,特别是伴胰岛素抵抗的高胰岛素血症和高雄激素血症,两者在PCOS的病理生理过程中发挥关键作用。肥胖易加重PCOS患者的胰岛素抵抗和高雄激素血症,导致肥胖型PCOS患者更易并发2型糖尿病、心血管疾病等远期并发症,同时因此而产生的多毛、痤疮及不孕等典型表现易导致PCOS患者焦虑、抑郁等心理疾病的发生率升高。Polycystic ovary syndrome （PCOS） is the most common endocrine and metabolic disorder in fertile-aged women. PCOS, a highly heterogeneous disease in clinical feature,is one of the main causes of infertility due to anovulation,which affects 5% to 10% of fertile-aged women. Obesity is strongly associated with the PCOS. There are about 50% of PCOS women with overweight or obesity,most of them being abdominal obesity. Obesity is related to a series of metabolic disorders, especially hyperinsulinemia with insulin resistance and hyperandrogenism, which play a pivotal role in the pathophysiological mechanisms of PCOS. Obesity can independently exacerbate insulin resistance and hyperandrogenism,whieh lead to the high risk of type 2 diabetes and cardiovascular disease in obese PCOS women. In addition,hirsutism,acne and infertility,the typical clinical manifestations, could cause the increasing depression and anxiety in PCOS women.

关 键 词：多囊卵巢综合征 肥胖症 瘦素 胰岛素抗药性 雄激素增多症 

分 类 号：R711.75[医药卫生—妇产科学]