胰岛素样生长因子-Ⅰ及其在头颈部肿瘤中的研究现状与展望  

Present research on the status and the prospect of insulin-like growth factor-Ⅰ in head and neck cancer

作　　者：刘秀虹[1,2] 蒋立新[1] 

机构地区：[1]暨南大学附属第一医院耳鼻咽喉头颈外科,广州510630 [2]广州市番禺区南村医院五官科,广州511442

出　　处：《临床耳鼻咽喉头颈外科杂志》2012年第15期717-720,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：胰岛素样生长因子（insulin-like growth fac-tors,IGFs）是由Salman和Daughaday于1957年首先发现的,当时被命名为＂硫化因子＂（sulfationfactors）,随着对其生理功能的不断了解,曾经被命名为＂生长介素＂（somatomedins,SM）、NSILA（nonsuppressible insulin-like activity）,1987年研究人员分离纯化了人的2种NSILA。Summary Insulin-like growth factor-Ⅰ （IGF-Ⅰ） is a multifunctional cell regulating factor, which plays an important role in the normal physiological activities and pathological process, This article reviewed the research status of the molecular structure of IGF-Ⅰ and its regulatory factors,the molecular biological role of IGF-Ⅰ in cell proliferation, cell motility, apoptosis, and reviewed the important role of IGF-Ⅰ in head and neck tumors, as well as put forward the prospects of IGF-Ⅰ in middle ear cholesteatoma pathogenesis.

关 键 词：胰岛素样生长因子-Ⅰ 细胞增殖 细胞迁移 凋亡 头颈部肿瘤 胆脂瘤 中耳 

分 类 号：R739.91[医药卫生—肿瘤]