丁苯酞脑缺血治疗作用的相关药理学研究进展  

Research progress of pharmacological study on butylphthalide Butylphthalide related to the treatment of cerebral ischemia and protect the brain pharmacological research progress

作　　者：端木寅[1] 王源[1] 梁爽[1] 顾晨晨[1] 冯怡[1] 

机构地区：[1]上海中医药大学中药现代制剂技术教育部工程研究中心,上海201203

出　　处：《中药药理与临床》2012年第3期126-130,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家教育部科学技术研究重点项目(No 211060);上海市科委上海市自然科学基金项目(11ZR1434500);上海市教委重点学科第五期中药药剂学项目(No J50302);上海市教育委员会科研创新项目重点项目(No 11zz112)

摘　　要：丁苯酞是治疗脑缺血等脑部疾病的一种疗效显著的药物,临床主要用于治疗轻、中度急性缺血性脑卒中等心脑血管疾病。近十多年来国内外大量实验证实丁苯酞可阻断缺血性脑卒中所致脑损伤的多个病理环节,具有较强的抗脑缺血作用、明显缩小大鼠局部脑缺血的梗塞面积、减轻脑水肿、改善脑能量代谢和缺血脑区的微循环和血流量、抑制神经细胞凋亡,以及抗脑血栓形成和抗血小板聚集等药理作用。本文就丁苯酞的药理作用、药代动力学、临床应用等面进行综述及展望。Butylphthalide has an obvious effect on mild-to-moderate acute ischemic stroke and other cardiovascular and cerebrovascular diseases in clinic. Over the past decades, many studied had confirmed that butylphthalide could block ischemic stroke-induced brain damage in multiple pathological links, including the protective effects on the brain injury induced by cerebral ischemia, reduction of the infarct size of focal cere- bral ischemia, improvement of brain energy metabolism and the microcirculation and blood flow of ischemic brain regions, inhibition of neuro- nal apoptosis, and inhibition of platelet aggregation and thrombosis. This paper retrospectively reviews the literature on butylphthalide and summarizes its Dharmacolozv. Dharmacokinetics and clinical annlications.

关 键 词：丁苯酞 缺血性脑卒中 药效学 药动学 

分 类 号：R965[医药卫生—药理学]