脂肪分布对不同年龄正常人群骨密度的影响  

The effect of fat distribution on bone mineral density in normal subjects

作　　者：易波[1] 文重远[1] 孙永林[1] 蔡玉立[1] 

机构地区：[1]武汉大学人民医院内分泌科,武汉430060

出　　处：《中国骨质疏松杂志》2012年第7期610-613,617,共5页Chinese Journal of Osteoporosis

摘　　要：目的探讨体质指数(BMI)、腹部脂肪、臀部脂肪对不同年龄正常人群骨密度的影响。方法采用双能X线BMD仪和医用身高体重测量仪测定393名正常体检人群腰椎松质骨密度、腹部脂肪含量、臀部脂肪含量、全身其他部位脂肪含量和身高、体重、腰围、臀围,并计算BMI和腰臀比。然后将人群按不同年龄分为青年组、中年组和老年组,分析骨密度与不同部位脂肪含量的关系。结果 (1)体内脂肪含量随年龄增加而增加,女性比男性的变化趋势更明显(P<0.05);(2)在中年患者中,BMI与骨密度成正相关(男性组r=0.237,P=0.018;女性组r=0.279,P=0.024);(3)老年男性患者腹部脂肪含量和臀部脂肪含量与骨密度成正相关(P<0.05)。而老年女性患者腹部脂肪含量与骨密度成负相关(r=0.263,P<0.05)。结论脂肪分布对骨密度的影响是复杂的,其中腹部脂肪和臀部脂肪可能是影响老年男性骨密度的主要因素,腹部脂肪是中老年女性骨密度的重要负调节因素。因此对中老年患者需注意减肥方式,以避免骨量的丢失和骨质疏松的形成。Objective The aim of this study is to investigate the effects of body mass index （BMI） , abdominal fat and hip fat on bone mineral density（BMD） in normal people of different ages. Methods A total of 393 subjects were studied in this study conducted from 2010 to 2011. The subjects were divided into youth groups, middle-aged and elderly groups according to their ages. We measured the height, weight, waist circumference and hip circumference, and then calculated BMI and WHR. BMD, abdominal fat and hip fat were measured by dual-energy X-ray. The relationship of bone mineral density and fat distribution were analyzed. Results 1, Fat mass increased with age, and the trends in women were more obvious than in men （P 〈 0. 05 ）; 2, In the middle-aged patients, BMI was positively correlated with BMD （male： r = O. 237, P = O. 018 ; female ： r = 0. 279, P = 0. 024） ; 3, In old male subjects group, abdominal fat and hip fat were positively correlated with bone mineral density （P 〈 0. 05 ）. As for the aged female, abdominal fat mass was negatively correlated with BMD （ r = 0. 263 ,P 〈 0.05）. Conclusion The effect of fat distribution on bone mineral density in normal subjects is perplexing Lose weight should not be overly emphasized in middle-aged patients or elderly people because it may led lo bone mass loss and osteoporosis formation.

关 键 词：骨密度 体质指数 脂肪含量 

分 类 号：R681[医药卫生—骨科学]