高甘油三酯及非诺贝特处理对老年雌性大鼠骨密度的影响  

The effects of hypertriglyceridemia and fenofibrate treatment on bone mineral density in elderly female fats

作　　者：张彤[1] 李万根[2] 

机构地区：[1]广州医学院第一附属医院内分泌科,510120 [2]广州医学院第二附属医院内分泌科

出　　处：《中国骨质疏松杂志》2012年第7期653-655,共3页Chinese Journal of Osteoporosis

基　　金：广东省卫生厅资助课题(编号A2008261)

摘　　要：目的探讨高甘油三酯及非诺贝特对老年雌性大鼠骨密度的影响。方法老年雌性大鼠30只随机分为3组:果糖组、非诺贝特组和普饲组,果糖组在普通饲料的基础上加入果糖,非诺贝特组在果糖的基础上加入非诺贝特。12周后取血处死,测血甘油三酯水平,留右侧股骨和第3～6腰椎测骨密度。结果果糖组的甘油三酯水平高于非诺贝特组和普饲组(P均<0.01);后两组间的甘油三酯水平无统计学差异。果糖组的腰椎和股骨的骨密度均低于非诺贝特组和普饲组(P均<0.01);后两组两个部位的骨密度均无统计学差异。结论高甘油三酯可以引起老年雌性大鼠骨质疏松,使用非诺贝特可以防治此类骨质疏松。Objective To explore the effects of hypertriglyceridemia and fenofibrate treatment on bone mineral density （BMD）. Methods Elderly female fats were divided into 3 groups, fructose group, fenofibrate group, and ordinary group according to their diet. All rats were sacrificed after 12 weeks. Blood triglyceride and BMD of the right femur and the lumbar vertebra 3-6 were measured. Results Triglyceride level was higher in fructose group than in fenofibrate group and ordinary group （P 〈 0.01 ）. BMD of both sites in fructose group were lower than that in fenofibrate group and ordinary group （ P 〈 0. O1 ）. There was no difference of BMD between the later two groups. Conclusion Hypertriglyceridemia causes osteoporosis in elderly female fats and fenofibrate can prevent hypertriglyceridemia-induced osteoporosis.

关 键 词：骨质疏松 甘油三酯 非诺贝特 

分 类 号：R681[医药卫生—骨科学]