骨质疏松动物模型研究进展  

Research progress in osteoporotic models

作　　者：王振恒[1] 赵建宁[1] 王瑞[1] 

机构地区：[1]南京军区南京总医院骨科,南京210002

出　　处：《中国骨质疏松杂志》2012年第7期656-662,共7页Chinese Journal of Osteoporosis

基　　金：国家自然基金青年科学基金项目(批准号:81000792);江苏省博士后基金面上项目(批准号:0902062C);中国博士后基金特别资助项目(批准号:201003793)

摘　　要：骨质疏松症(osteoporosis)是一种以骨量减少和骨组织微观结构退化为特征,骨的脆性增加,易发生骨折的全身性骨骼疾病。在骨质疏松症的研究中,根据研究目的,选择合适的动物模型尤为重要。各种动物模型都有其自身的特点和优势,各种造模方法也各有侧重,本文对此做一综述。Osteoporosis is defined as a systemic disease characterized by loss of bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture. According to purpose of one＇ s research to select a suitable animal model is critical. Various kinds of animal models hold their own features and superiorities and the manufactures of animal models place extra emphasis on different aspects. This paper tries to make a review on these.

关 键 词：骨质疏松 动物模型 去势法 大鼠 

分 类 号：R681[医药卫生—骨科学]