两种不同挥发油含量柴胡制剂药效作用研究  

Pharmacodynamic study on two different content of volatile oil in Bupleurum

作　　者：周王谊[1] 李欣欣[1] 莫红梅[1] 杨建会[2] 

机构地区：[1]天津天士力集团研究院,天津300410 [2]天津天士力制药股份有限公司,天津300410

出　　处：《中药药理与临床》2012年第1期104-106,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:对比两种不同挥发油含量柴胡制剂的抗炎、镇痛、解热作用。方法:分别采用二甲苯致炎剂所致小鼠耳廓肿胀实验,醋酸引起小鼠疼痛扭体实验,干酵母致大鼠发热实验,观察两种柴胡制剂的抗炎、镇痛、解热作用,并比较二者差异。结果:采用抗炎、镇痛、解热三种动物模型研究表明,普通柴胡浸膏5g生药/kg、10g生药/kg,富集挥发油的柴胡浸膏5g生药/kg、10g生药/kg均可显著减轻二甲苯所致的小鼠耳肿胀,减少醋酸所致的小鼠扭体反应次数,降低干酵母引起的大鼠体温升高,其中富集挥发油的柴胡浸膏的抗炎活性优于普通柴胡浸膏,但镇痛和解热活性两种浸膏无显著性差异。结论:两种不同挥发油含量柴胡浸膏均具有明显的抗炎、镇痛和解热作用,但柴胡挥发油抗炎活性较高。Objective： Compare two different formulations of the volatile oil content of Bupleurum Pharmacodynamic effect.Methods： The proinflammatory agent xylene-induced ear swelling experiments,anti-inflammatory agents observed Bupleurum;pain in mice using acetic acid induced writhing test,the analgesic effect observed Bupleurum agents;caused by a large dry yeast Rat fever experiments,observations Bupleurum antipyretic agents.Results： Ordinary Bupleurum extract 5g crude drug/kg·d,10g crude drug/kg·d,essential oil of Bupleurum extract enriched 5g of crude drug/kg·d,10g crude drug/kg·d can be significantly reduced Bupleurum xylene-induced mouse ear swelling,to reduce the acetic acid-induced writhing reaction times,lower dry yeast-induced fever in rats.Conclusion： Two different formulations were Bupleurum volatile oil content has a significant anti-inflammatory,analgesic and antipyretic effects,anti-inflammatory activity of essential oil of Bupleurum extract concentration than normal extracts;analgesic,antipyretic activity there was no significant differences.

关 键 词：柴胡制剂 抗炎 镇痛 解热 

分 类 号：R285[医药卫生—中药学]