胶质瘤组织中Per2和PCNA的表达及其相关性  

Expression and correlation of Per 2 and PCNA in glioma

作　　者：王凡[1] 陈治军[1] 罗勇[1] 刘平非[1] 陈吕安[1] 夏鹤春[2] 

机构地区：[1]荆门市第一人民医院,湖北荆门448000 [2]宁夏医科大学附属医院

出　　处：《山东医药》2012年第26期7-9,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30860289)

摘　　要：目的观察胶质瘤组织中节律基因Per2和增殖细胞核抗原(PCNA)的表达变化,探讨其相关性及二者与胶质瘤临床病理特征的关系。方法采用免疫组化ABC法检测37例胶质瘤组织及瘤周组织中的Per2和PC-NA。结果胶质瘤组织中,Per2阳性表达率为29.7%(11/37),明显低于瘤周组织的62.2%(23/37);PCNA阳性表达率为100%,明显高于瘤周组织的0(P均<0.05)。高分化胶质瘤组织中Per2、PCNA强阳性表达率分别为16.7%8、8.9%,低分化者分别为42.1%、26.1%,二者Per2、PCNA的表达差异具有统计学意义(P均<0.05)。胶质瘤组织中Per2与PCNA的表达呈负相关(r=-0.492,P<0.05)。结论胶质瘤组织中Per2的表达下调、PCNA表达上调,Per2与PCNA的表达呈负相关关系;Per2、PCNA与胶质瘤分化程度有关。Objective To investigate the expression and correlation of Per2 and PCNA in glioma, and the relationship in Per2 and PCNA with clinicopathologic features. Method The expression of Per2 and PCNA in 37 cases of gliomas and nontumor tissues was detected by immunohistochemical ABC method. Results The positive rate of Per2 was lower, and PCNA was higher in glioma tissue than that in nontumor one （ all P 〈 0.05 ）. There was a negative correlation between the expression of Per2 and PCNA in gliomas （r = -0.492, P 〈 0.05 ）. Conclusions The Per2 is lowely and the PCNA is higherly expressed in glioma tissue, and there is a negative correlation. The expression of Per2 and PCNA may be a mechanism in occurrence and progression of gliomas.

关 键 词：颅内肿瘤 胶质瘤 节律基因 增殖细胞核抗原 

分 类 号：R651.1[医药卫生—外科学]