氨基膦氧类有机小分子催化剂的制备及其催化的对N-取代苯乙酮亚胺的不对称硅氢化还原  

Preparation of Chiral Aminophosphinyl Oxides and Their Application in Asymmetric Reduction of N-substituted Acetophenone Ketimine

作　　者：李扬[1,2] 伍辛军[1] 王超[1] 孙健[1] 

机构地区：[1]中国科学院成都生物研究所天然产物中心,四川成都610041 [2]中国科学院研究生院,北京100049

出　　处：《合成化学》2012年第4期497-500,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(20732006;20972152)

摘　　要：首次利用L-酒石酸和L-扁桃酸对吡咯烷/哌啶衍生的氨基膦氧化合物进行拆分制得高对映选择性的氨基膦氧类有机小分子催化剂。将其应用于N-取代苯乙酮亚胺的不对称硅氢化还原反应中,以中等收率和对映体选择性获得相应的N-取代苯基手性胺。Aminophosphinyl oxides（Ⅰ-Ⅳ） with high enantioselectivity were prepared by resolution of aminophosphinyl oxides which derived from pyrrolidine and piperidine using L-tartaric acid and L-mandelic acid as the resolution agent for the first time.Ⅰ-Ⅳ were further applied as organic catalyst in the asymmetric hydrosilylation of N-substituted acetophenone ketimine by HSiCl3 to give chiral N-substituted-pheny amine in moderate yield and enantioselectivity.

关 键 词：氨基膦氧 LEWIS碱 有机小分子催化剂 不对称硅氢化 制备 

分 类 号：O629.71[理学—有机化学]