罗哌卡因和布比卡因对豚鼠心室乳头肌动作电位的影响  

Action of bupivacaine and ropivacaine on guinea pig papillary muscle action potential

作　　者：吕安祺[1] 郑燕倩 杭燕南[1] 闻大翔[1] 孙晔 

机构地区：[1]上海第二医科大学仁济医院麻醉科,200001

出　　处：《中华麻醉学杂志》2000年第2期105-107,共3页Chinese Journal of Anesthesiology

摘　　要：目的　观察罗哌卡因和布比卡因对豚鼠心室乳头肌纤维动作电位的影响。方法　用含罗哌卡因和布比卡因 1、3、5 μg·ml-1的台氏液分别灌流豚鼠心室乳头肌 ,记录用药前、用药后及药物洗脱后动作电位各参数的改变 :动作电位幅值 (APA)、动作电位 0时相最大上升速度 (Vmax)、动作电位5 0 %复极时程 (APD50 )及动作电位 90 %复极时程 (APD90 )。结果　各浓度局麻药均抑制Vmax,罗哌卡因 5 μg·ml-1抑制程度 (下降 2 7 4% )与布比卡因 3μg·ml-1(下降 2 8 4% )相似 ,与等浓度布比卡因 (下降42 6 % )相比呈显著性降低 (P <0 0 5 )。罗哌卡因和布比卡因 5 μg·ml-1均明显抑制APA ,分别下降2 5 6 %和 5 98%。罗哌卡因 5 μg·ml-1使APD50 和APD90 分别缩短 1 86 %和 1 6 % ,明显小于等浓度布比卡因 (7 2 3%和 4 96 % )。结论　罗哌卡因对心室乳头肌动作电位的影响较布比卡因小 。Objective To evaluate the effects of bupivacaine and ropivacaine on guinea pig papillary muscle action potential Methods The guinea pig papillary muscle preparation was exposed to ropivacaine (1, 3 or 5μg·ml -1 ) or bupivacaine ( 1, 3 and 5μg·ml -1 ) respectively, to measure maximum rate of depolarization (Vmax ), action potential amplitude (APA),action potential duration at 50% of repolarization(APD 50 ), and action potential duration at 90% of repolarization(APD 90 ) Results Vmax significantly decreased after exposure to both agents at all concentrations, Vmax decreased by 27 4% with ropivacaine at 5μg·ml -1 , and the degree was similar to that with bupivacaine at 3 μg·ml -1 (28 4%) ,but was significantly lower than that with bupivacaine at 5 μg·ml -1 (42 6%) (P<0 05) At ropivacaine of 5 μg·ml -1 APA decreased by 2 56%, APD 50 by 1 86% and APD 90 by 1 60%, the degrees were significantly less than those at the equal concentration of bupivacaine (5 98% , 7 23% and 4 96%) (P<0 05) Conclusions Ropivacaine is less potent than bupivacaine on cardiac action potential,either cardiotoxicity is related to the inhibition on sodium channel to depress cardiac excitability and conduction.

关 键 词：罗哌卡因 布比卡因 动作电位 心室乳头肌 

分 类 号：R965[医药卫生—药理学]