磁导向甲氨蝶呤缓释药物的药学参数检测  

Determination of pharmaceutical parameters of ferromagnetic methotrexate albumin microspheres

作　　者：张皖清[1] 孙玉鹏[2] 毛天球[1] 何远辉[3] 徐来斌[4] 

机构地区：[1]第四军医大学口腔医学院,710032 [2]解放军304医院骨科 [3]西南应用磁学研究所 [4]西安近代化学研究所

出　　处：《实用口腔医学杂志》2000年第1期65-67,共3页Journal of Practical Stomatology

基　　金：国家自然科学基金!资助项目390 70 871;国家新药基金!资助项目 93- (62 ) - N- 4 2

摘　　要：目的:探讨磁导向甲氨蝶呤缓释药物(FM-MTX)的药学参数。方法:采用分光光谱法、高效液相色谱法、原子吸收光谱法检测磁导向甲氨蝶呤缓释药物的含量及组成,并对FM-MTX的比重、沸点、粒径和稳定性进行检测。结果:HPLC法检测FM-MTX中MTX药物含量为260mg/L。Fe3O4平均含量为66.29mg/L。FM-MTX粒度分布均匀,粒径为0.4～1.0μm,占88.61%。FM-MTX药物含量稳定,放置6个月,含量未见明显变化。Objective: To determine pharmaceutical parameters of magnetic targeted ferromagnetic albumin methotrexate conjugates (FM MTX) as a slow release antitumor drug.Methods:The pharmaceutical parameters of FM MTX were determined with ultraviolet spectrophotometry,high performance liquid chromatography (HPLC) and atomic absorption spectrophotometry.Results:The mean content of methotrexate in FM MTX was 260 mg/L and Fe 3O 4 66.29 mg/L. The diameter of FM MTX particles was 0.8～1.0 μm.The measurements of the preparation were stable within 6 months.Conclusion:FM MTX is stable in both contents and particle size.

关 键 词：甲氨蝶呤 磁微球 靶向给药系统 抗癌药 

分 类 号：R927.1[医药卫生—药学]