磁导向甲氨蝶呤缓释药物的形貌特征及缓释特性  

The morphology and slow release characters of ferromagnetic methotrexate albumin microspheres

作　　者：张皖清[1] 孙玉鹏[2] 毛天球[1] 何远辉[3] 徐来斌[4] 

机构地区：[1]第四军医大学口腔医学院,710032 [2]北京304医院 [3]西南应用磁学研究所 [4]西安近代化学研究所

出　　处：《实用口腔医学杂志》2000年第1期68-70,共3页Journal of Practical Stomatology

基　　金：国家自然科学基金!资助项目390 70 871;国家新药基金!资助项目 93- (62 ) - N- 4 2

摘　　要：目的:探讨磁导向甲氨蝶呤缓释药物(FM-MTX)的形貌特征及缓释特性。方法:采用分光光谱法、扫描电镜、透射电镜、X射线能谱分析等手段检测磁导向甲氨蝶呤缓释药物的含量及组成,并对FM-MTX的形貌特征及缓释特性进行检测。结果:化学交联法制备出磁导向甲氨蝶呤白蛋白缓释药物,其药物含量稳定。颗粒直径约(0.8±0.14)μm。在梯度磁场下比磁矩σs为0.9A·m2/kg。在0.9%氯化钠及RPMI1640培养液6h仅有30.5%药物释放到介质中,24h释药量约60%,48h接近78%。结论:以化学交联法制得的磁导向甲氨蝶呤缓释药物FM-MTX含量稳定。Objective: To study the morphology and slow release characters of magnetic targeted ferromagnetic albumin methotrexate conjugates (FM MTX) as an antitumor drug.Methods:The morphology and slow release characters of FM MTX were studied with ultraviolet spectrophotometry,transmission electron microscope,scanning electron microscopy and energy dispersive analysis of X ray.Results:Particle diameter of FM MTX was (0.8±0.14) μm.The magnetic strength of FM MTX σ s was 0.9 A·m 2/kg. About 30.5 % of MTX were released into mediums by 6 h,about 60% by 24 h,approximately 78% by 48 h.Conclusion:The pharmaceutical parameters of FM MTX are stable with slow release characters within 48 h in vitro .

关 键 词：甲氨蝶呤 磁微球 缓释制剂 

分 类 号：R943[医药卫生—药剂学]